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New treatment option for Oral Mucositis Due to Chemotherapy
Official title Using a Steroid Mouthwash to Prevent Mouth Sores During Chemotherapy
ClinicalTrials.gov ID: NCT07287826
What this study is testing
What is Dexamethasone Mouthwash?
Dexamethasone Mouthwash is an investigational medicine, given as an once-weekly infusion into a vein, being studied as a potential treatment for oral mucositis due to chemotherapy.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn if a steroid mouthwash (dexamethasone) can prevent mouth sores caused by chemotherapy in adults with cancer. The main questions it aims to answer are: Does using dexamethasone mouthwash before and during chemotherapy lower the chance of getting moderate to severe mouth sores?
- Phase 4: studies an already-approved treatment
- Time commitment: about 8 weeks
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- ≥18 years old
- Confirmed cancer diagnosis
- Scheduled to receive or receiving chemotherapy known to be associated with oral mucositis (e.g., anthracyclines and taxanes)
- Ability to provide informed consent
- Ability to comply with study procedures
You likely can't join if
- Current tobacco usage or usage within the past 6 weeks.
- HIV/AIDS
- Gastrointestinal disorder (such as Crohn's disease, ulcerative colitis, or celiac disease)
- History of cold sores (herpes simplex virus)
- Herpes zoster (oral shingles) within the past 6 weeks
- Active oral infections at the time of enrollment (e.g., candidiasis)
See the full eligibility criteria
- ≥18 years old
- Confirmed cancer diagnosis
- Scheduled to receive or receiving chemotherapy known to be associated with oral mucositis (e.g., anthracyclines and taxanes)
- Ability to provide informed consent
- Ability to comply with study procedures
- Current tobacco usage or usage within the past 6 weeks.
- HIV/AIDS
- Gastrointestinal disorder (such as Crohn's disease, ulcerative colitis, or celiac disease)
- History of cold sores (herpes simplex virus)
- Herpes zoster (oral shingles) within the past 6 weeks
- Active oral infections at the time of enrollment (e.g., candidiasis)
- Known sensitivity or allergy to dexamethasone
- Inability to self-administer or tolerate mouthwash protocol
- Concurrent enrollment in conflicting clinical trials
- Existing oral ulcers or oral mucositis at enrollment
- Pregnant
- Uncontrolled diabetes mellitus as defined by HbA1c unknown or \>8% in the past 3 months despite adequate therapy
The study team makes the final eligibility decision.
Where it's taking place
- Baton Rouge, Louisiana, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 8 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baton Rouge, Louisiana, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.