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New treatment option for Cirrhosis, Liver
Official title Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
ClinicalTrials.gov ID: NCT07286643
What this study is testing
- What it's testing
- Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and Severe Sepsis. Due to portal hypertension, these patients have a hyperdynamic circulation, increased capillary permeability, splanchnic arteriolar vasodilation, reduced effective circulating blood volume and may have latent cirrhotic cardiomyopathy (CCM).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Critically ill patient with cirrhosis of any etiology
- Sepsis-related Hypotension (MAP \<65mmHg or SBP \<90mmHg)
- 18-65 yrs of age -
You likely can't join if
- Already on vasopressors/inotropes
- Severe pre-existing cardiopulmonary disease like porto-pulmonary hypertension (PPH), known coronary artery disease, congenital or valvular heart...
- Poor chest wall window due to left pleural effusion, left pneumothorax, small intercostal spaces that restrict performance of a POCUS.
- Active bleeding like variceal bleed
- Cerebrovascular events
- Chronic renal disease - End Stage Renal Disease (ESRD)/ patient on renal replacement therapy
See the full eligibility criteria
- Critically ill patient with cirrhosis of any etiology
- Sepsis-related Hypotension (MAP \<65mmHg or SBP \<90mmHg)
- 18-65 yrs of age -
- Already on vasopressors/inotropes
- Severe pre-existing cardiopulmonary disease like porto-pulmonary hypertension (PPH), known coronary artery disease, congenital or valvular heart disease, prosthetic cardiac valves, dilated or restrictive cardiomyopathy.
- Poor chest wall window due to left pleural effusion, left pneumothorax, small intercostal spaces that restrict performance of a POCUS.
- Active bleeding like variceal bleed
- Cerebrovascular events
- Chronic renal disease - End Stage Renal Disease (ESRD)/ patient on renal replacement therapy
- Admission to ICU following liver transplantation, burns, cardiac surgery
- Previous transjugular intra hepatic portosystemic shunt (TIPS),
- Hepatocellular carcinoma
- Pregnant or lactating women
- Informed consent refused by patient or attendants
- Active COVID-19 infection
The study team makes the final eligibility decision.
Where it's taking place
- Chandigarh, India
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Chandigarh, India. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.