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New treatment option for Copd
Official title Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov ID: NCT07285642
What this study is testing
- What it's testing
- This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD). Functional near-infrared spectroscopy (fNIRS) and near-infrared spectroscopy (NIRS) will be used simultaneously to measure oxygenation changes in the prefrontal cortex and the vastus lateralis muscle during rest, Stroop task performance, the six-minute walk test, aerobic, strengthening, and breathing exercises.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Age 40-70 years
- Diagnosis of moderate-to-severe COPD (GOLD stage II-III)
- Stable disease (no exacerbation in previous 4 weeks)
- BMI 18.5-24.9 kg/m²
- Manual muscle strength ≥ 4 (MRC scale)
You likely can't join if
- Severe comorbid conditions (uncontrolled cardiac, neurological, or orthopedic disease)
- Need for high-flow oxygen therapy (\>2 L/min)
- History of cerebrovascular disease or transient ischemic attack
- Musculoskeletal or dermatological conditions impairing NIRS measurement sites
- Restrictive lung disease, interstitial lung disease, or small-airway disease
- Participation in an exercise program within the last 12 months Healthy Controls
See the full eligibility criteria
- Age 40-70 years
- Diagnosis of moderate-to-severe COPD (GOLD stage II-III)
- Stable disease (no exacerbation in previous 4 weeks)
- BMI 18.5-24.9 kg/m²
- Manual muscle strength ≥ 4 (MRC scale)
- Ability to perform exercise tests safely
- Written informed consent
- Severe comorbid conditions (uncontrolled cardiac, neurological, or orthopedic disease)
- Need for high-flow oxygen therapy (\>2 L/min)
- History of cerebrovascular disease or transient ischemic attack
- Musculoskeletal or dermatological conditions impairing NIRS measurement sites
- Restrictive lung disease, interstitial lung disease, or small-airway disease
- Participation in an exercise program within the last 12 months Healthy Controls
- Age 40-70 years
- No acute or chronic disease
- Non-smoker
- BMI 18.5-24.9 kg/m²
- No musculoskeletal limitations
The study team makes the final eligibility decision.
Where it's taking place
- Istanbul, Turkey (Türkiye)
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Istanbul, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.