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New treatment option for Histamine
Official title Histamines and Central Hemodynamics
ClinicalTrials.gov ID: NCT07285031
What this study is testing
What is Diphenhydramine hydrochloride?
Diphenhydramine hydrochloride is an investigational medicine, being studied as a potential treatment for histamine.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 to 39. Healthy volunteers may be eligible.
You may be able to join if
- Age: 19 - 39.
- Willing to visit the lab on 3 separate occasions.
You likely can't join if
- Previously diagnosed heart condition,
- Previously diagnosed lung condition (including asthma),
- Previously diagnosed metabolic condition,
- Currently smokers (cigarettes, electronic cigarettes, cannabis) or who have smoked within the last 3 months,
- Resting blood pressure \>140/90 mmHg,
- Unable to obtain appropriate quality ultrasound images of the heart.,
See the full eligibility criteria
- Age: 19 - 39.
- Willing to visit the lab on 3 separate occasions.
- Previously diagnosed heart condition,
- Previously diagnosed lung condition (including asthma),
- Previously diagnosed metabolic condition,
- Currently smokers (cigarettes, electronic cigarettes, cannabis) or who have smoked within the last 3 months,
- Resting blood pressure \>140/90 mmHg,
- Unable to obtain appropriate quality ultrasound images of the heart.,
- Individuals without tricuspid regurgitation at rest to allow assessment of the primary outcome,
- Pregnant or trying to become pregnant,
- Breastfeeding,
- Chronically take antihistamines (i.e. daily),
- History of adverse reactions to antihistamines,
- Never taken antihistamines previously,
- Currently taking any medications (including oral contraceptives).
The study team makes the final eligibility decision.
Where it's taking place
- Kelowna, British Columbia, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 19 years to 39 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kelowna, British Columbia, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.