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New treatment option for Dementia With Lewy Bodies
Official title Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia
ClinicalTrials.gov ID: NCT07284290
What this study is testing
What is Galantamine HBr extended-release 8mg capsules (8mg ER).?
Galantamine HBr extended-release 8mg capsules (8mg ER). is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for dementia with lewy bodies.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The proposed study aims to address the critical gaps in understanding the mechanisms of CF (Cognitive Fluctuations) by leveraging recently emerged molecular biomarkers, advanced neuroimaging techniques to assess measures of cholinergic degeneration, and synchronous EEG and assessments of attention. One of the overarching innovations of study is combining all of these assessments into one integrated research plan
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 89. Healthy volunteers may be eligible.
You may be able to join if
- Arm 1:
- Age range: 50 ≤ age \< 90.
- Diagnosis of dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), Parkinson disease with Mild Cognitive Impairment (PD-MCI), Mild...
- DLB participants must fulfill criteria for clinically probable DLB based on the 2017 4th consensus report of the DLB consortium.
- PDD participants must meet criteria for clinically probable PD according to the MDS Clinical Diagnostic Criteria for Parkinson's Disease and must...
You likely can't join if
- Arm 1
- History of cognitive disorder or psychiatric disorder other than that related to dementia with Lewy bodies or Parkinson disease dementia.
- History of deep brain stimulation or any neurosurgical procedure.
- History of structural brain disease or known significant cerebrovascular disease.
- History of seizures or epilepsy and/or use of sodium channel blockers, i.e. carbamazepine, oxcarbazepine, phenytoin, topiramate, lamotrigine...
- Greater than two alcoholic drinks per day for men and one per day for women.
See the full eligibility criteria
- Arm 1:
- Age range: 50 ≤ age \< 90.
- Diagnosis of dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), Parkinson disease with Mild Cognitive Impairment (PD-MCI), Mild Cognitive Impairment with Lewy bodies (MCI-LB).
- DLB participants must fulfill criteria for clinically probable DLB based on the 2017 4th consensus report of the DLB consortium.
- PDD participants must meet criteria for clinically probable PD according to the MDS Clinical Diagnostic Criteria for Parkinson's Disease and must also meet criteria for probable PDD based on the 2007 Movement Disorders...
- PD-MCI participants must meet criteria for clinically probable PD according to the MDS Clinical Diagnostic Criteria for Parkinson's Disease and meet criteria for Mild Cognitive Impairment on cognitive testing at...
- MCI-LB participants with must meet established research criteria.
- Capacity to provide informed consent or, if unable, availability of a legally authorized representative or guardian who can provide informed consent.
- Availability of informant (for participants meeting criteria for dementia).
- Ability and willingness to comply with the study-related procedures.
- Fluent in spoken and written English (due to cognitive testing)
- Arm 1
- History of cognitive disorder or psychiatric disorder other than that related to dementia with Lewy bodies or Parkinson disease dementia.
- History of deep brain stimulation or any neurosurgical procedure.
- History of structural brain disease or known significant cerebrovascular disease.
- History of seizures or epilepsy and/or use of sodium channel blockers, i.e. carbamazepine, oxcarbazepine, phenytoin, topiramate, lamotrigine, felbamate, zonisamide, rufinamide, lacosamide, eslicarbazepine, and valproate.
- Greater than two alcoholic drinks per day for men and one per day for women.
- Regular use of benzodiazepines or barbiturates. (If benzodiazepines are taken as needed only, these medications cannot be taken within 5 half-lives of screening visit or between screening visit and EEG.)
- Severe dementia (based on PI assessment of subject dependence level for instrumental activities of daily living)
- Any contraindication to brain MRI.
- Any medical condition that would interfere with ability to complete all study procedures.
- Participants must not be pregnant, planning to become pregnant, or father a child for the duration of the study Inclusion Criteria: Arm 2 (Cholinesterase inhibitor cohort) inclusion criteria:
- Completed Aim 1.
- Clinical diagnosis of LBD (DLB or PDD) with CF.
- Not taking a cholinesterase inhibitor and has not taken a cholinesterase inhibitor in the previous 90 days.
- Ability and willingness to comply with the ChEI Cohort procedures (including galantamine administration), or a caregiver willing and able to ensure compliance. Exclusion Criteria: Arm 2 (Cholinesterase inhibitor cohort)...
- Severe hepatic impairment.
- Renal failure.
- Significant bradycardia (\<50 bpm) at screening or history of AV block.
- Any contraindication to galantamine administration based on PI discretion. Inclusion criteria: Arm 3 (Healthy Controls)
- Age range: 50 ≤ age \< 90.
- Healthy controls should not have any known neurologic conditions that could interfere with study procedures or results.
- Capacity to provide informed consent or, if unable, availability of a legally authorized representative or guardian who can provide informed consent.
- Availability of informant (for participants meeting criteria for dementia).
- Ability and willingness to comply with the study-related procedures.
- Fluent in spoken and written English (due to cognitive testing). Exclusion Criteria: Arm 3 (Healthy Controls)
- No History of cognitive disorder or psychiatric disorder other than that related to dementia with Lewy bodies or Parkinson disease dementia.
- No History of deep brain stimulation or any neurosurgical procedure.
- No History of structural brain disease or known significant cerebrovascular disease.
- No History of seizures or epilepsy and/or use of sodium channel blockers, i.e. carbamazepine, oxcarbazepine, phenytoin, topiramate, lamotrigine, felbamate, zonisamide, rufinamide, lacosamide, eslicarbazepine, and...
- Any medical condition that would interfere with ability to complete all study procedures.
- Participants must not be pregnant, planning to become pregnant, or father a child for the duration of the study
The study team makes the final eligibility decision.
Where it's taking place
- Richmond, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 89 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Richmond, Virginia, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.