BridgeMD
New treatment option for Total Knee Arthroplasty
Official title Vancomycin in TKAs
ClinicalTrials.gov ID: NCT07282782
What this study is testing
What is Vancomycin?
Vancomycin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for total knee arthroplasty.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement. Within the realm of elective total knee arthroplasty (TKA), various methods of infection prophylaxis are in place.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Any patient over the age of 18 years of age receiving treatment at UC San Diego Health
- Undergoing primary unilateral TKA
- Ability to provide consent
You likely can't join if
- previous surgery on the knee (with the exception of arthroscopy)
- BMI \> 35
- contraindication to receiving vancomycin, cefepime or cefazolin (ie, allergy, etc)
- diabetics with A1c\>7.5% (unless controlled fructosamine)
- immunocompromised or immunosuppressed patients (HIV, Hepatitis C, end stage renal disease (ESRD), post transplant, chemotherapy or radiation therapy...
- no history of active infections
See the full eligibility criteria
- Any patient over the age of 18 years of age receiving treatment at UC San Diego Health
- Undergoing primary unilateral TKA
- Ability to provide consent
- previous surgery on the knee (with the exception of arthroscopy)
- BMI \> 35
- contraindication to receiving vancomycin, cefepime or cefazolin (ie, allergy, etc)
- diabetics with A1c\>7.5% (unless controlled fructosamine)
- immunocompromised or immunosuppressed patients (HIV, Hepatitis C, end stage renal disease (ESRD), post transplant, chemotherapy or radiation therapy within 6 months of surgery, immunomodulating meducations)
- no history of active infections
- no history of chronic kidney disease
The study team makes the final eligibility decision.
Where it's taking place
- San Diego, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Diego, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.