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New treatment option for Alzheimer s Disease
Official title Fisetin in Mild Alzheimer's Disease
ClinicalTrials.gov ID: NCT07279714
What this study is testing
- What it's testing
- This pilot study will evaluate the safety and tolerability of the natural health product, fisetin, in older adults with mild cognitive impairment or mild Alzheimer's disease dementia.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 and older
You may be able to join if
- Mild cognitive impairment due to Alzheimer's disease OR mild Alzheimer Dementia
- Moca score of 11 or higher
- Stable psychotropics and cognitive enhancing medications
You likely can't join if
- Known hypersensitivity or allergy to fisetin
- Presence of any medical condition, or abnormal routine blood test, that the investigator believes would put the subject at risk or would preclude the...
- Unstable medical disorders
- Ongoing treatment for active infection with antibiotics/antifungals
- Ongoing treatment for cancer
- Active alcohol or substance use disorder
See the full eligibility criteria
- Mild cognitive impairment due to Alzheimer's disease OR mild Alzheimer Dementia
- Moca score of 11 or higher
- Stable psychotropics and cognitive enhancing medications
- Known hypersensitivity or allergy to fisetin
- Presence of any medical condition, or abnormal routine blood test, that the investigator believes would put the subject at risk or would preclude the patient from completing all aspects of the trial
- Unstable medical disorders
- Ongoing treatment for active infection with antibiotics/antifungals
- Ongoing treatment for cancer
- Active alcohol or substance use disorder
- Recent active bleeding
- Patients taking oral anticoagulants, anti-cancer, anti-seizure medications, or other medications that could have a significant interaction with fisetin
- Use within the last month of other senolytic supplements, antioxidant supplements, natural health products
- Other neurologic or neurodegenerative conditions impacting cognition
- Active Major Depressive Episode, active suicidal thoughts or psychosis
- Any thing that would preclude the ability to undergo an MRI scan
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.