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New treatment option for PASC Post Acute Sequelae of COVID 19
Official title Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
ClinicalTrials.gov ID: NCT07278388
What this study is testing
- What it's testing
- This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75. Healthy volunteers may be eligible.
You may be able to join if
- Age 18 to 75 years old.
- Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et...
- Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire.
You likely can't join if
- Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or...
- Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
- Congestive heart failure.
- Peripheral artery disease with claudication.
- Cancer.
- Pulmonary or renal failure.
See the full eligibility criteria
- Age 18 to 75 years old.
- Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the...
- Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire.
- Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
- Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
- Congestive heart failure.
- Peripheral artery disease with claudication.
- Cancer.
- Pulmonary or renal failure.
- Unstable angina.
- Uncontrolled hypertension (more than 190/110 mmHg).
- Severe aphasia.
- Orthopedic or pain conditions.
- Have had exposure to metal or metal implants, due to the hazardous effects of the magnetic field.
- If on immunomodulatory therapy, they must have been on that therapy for at least 6 months before the start of the study. Healthy age- and sex-matched controls for PASC - Exclusion criteria: Participants with a history...
- Hospitalization due to SARS-CoV-2 infection.
- Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
- Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
- Congestive heart failure.
- Peripheral artery disease with claudication.
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.