BridgeMD
New treatment option for Long COVID
Official title Brain Stimulation in Long COVID
ClinicalTrials.gov ID: NCT07278206
What this study is testing
- What it's testing
- Cognitive problems and severe fatigue are two frequently occurring symptoms in long COVID, also known as Post-Covid Condition or Post-Acute Sequelae of COVID-19 (PASC), and their causes are currently unknown. Previous studies have shown reduced blood flow and increased inflammation in the brains of people with PASC.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Meet the World Health Organization (WHO) definition of long COVID.
- Aged 18 years or older.
- Severe fatigue, defined as a score ≥35 on the Checklist Individual Strength (CIS) fatigue subscale.
- Significant cognitive complaints, defined as a score ≥18 on the CIS concentration subscale.
- Commitment to actively undergo rTMS
You likely can't join if
- Prior rTMS treatment or current intensive/experimental treatment for long COVID.
- History of epilepsy or first-degree family history of epilepsy.
- Recent initiation or dosage change of psychotropic medication (less than six weeks for psychotropic medication including antidepressants and...
- Other active concurrent pharmacological treatments for post-covid symptoms
- Contraindications to MRI scanning (e.g., non-removable metallic implants, severe claustrophobia).
- Presence of a cochlear implant.
See the full eligibility criteria
- Meet the World Health Organization (WHO) definition of long COVID.
- Aged 18 years or older.
- Severe fatigue, defined as a score ≥35 on the Checklist Individual Strength (CIS) fatigue subscale.
- Significant cognitive complaints, defined as a score ≥18 on the CIS concentration subscale.
- Commitment to actively undergo rTMS
- Ability to attend the study site regularly for treatment sessions.
- Capacity to provide written informed consent.
- Prior rTMS treatment or current intensive/experimental treatment for long COVID.
- History of epilepsy or first-degree family history of epilepsy.
- Recent initiation or dosage change of psychotropic medication (less than six weeks for psychotropic medication including antidepressants and antipsychotic drugs, less than two weeks for benzodiazepines). Medication...
- Other active concurrent pharmacological treatments for post-covid symptoms
- Contraindications to MRI scanning (e.g., non-removable metallic implants, severe claustrophobia).
- Presence of a cochlear implant.
- Neurological disorders such as multiple sclerosis or other neurodegenerative conditions.
- Pregnancy.
- Known brain lesions or ischaemic scars influencing seizure threshold.
- Severe uncontrolled migraines.
- Severe cardiovascular disease
- Raised intracranial pressure.
- High alcohol consumption (males/females: 21/14 units per week) or use of epileptogenic drugs.
- Severe sleep deprivation at the time of treatment.
The study team makes the final eligibility decision.
Where it's taking place
- Amsterdam, Netherlands
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Amsterdam, Netherlands. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.