BridgeMD
New treatment option for Chronic Nausea and Vomiting Syndrome
Official title Brain-Stomach Circuits in Chronic Nausea
ClinicalTrials.gov ID: NCT07276035
What this study is testing
- What it's testing
- The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are: What are the best brain sites to influence the stomach?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report.
You likely can't join if
- body mass index (BMI) \> 30
- pregnancy or intention to become pregnant
- past or present chemotherapy
- diagnosis of gastric (stomach) cancer
- any kind of gastric (stomach) surgery
- current use of GLP-1 receptor agonists (e.g. Ozempic, Trulicity)
See the full eligibility criteria
- Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report.
- body mass index (BMI) \> 30
- pregnancy or intention to become pregnant
- past or present chemotherapy
- diagnosis of gastric (stomach) cancer
- any kind of gastric (stomach) surgery
- current use of GLP-1 receptor agonists (e.g. Ozempic, Trulicity)
- medications which significantly lower seizure thresholds (e.g. bupropion (Wellbutrin), fluoxetine (Prozac), or tramadol (Ultram))
- implantable devices, such as a pacemakers or nerve stimulators
- history of head injury that required hospitalization, metal in the skull, or neurologic disease such as stroke, history of seizures or history of syncope (fainting or passing out)
- neurodegenerative disease (Multiple Sclerosis, Parkinson's or Alzheimer's Disease)
- ongoing psychosis or altered cognitive status status (e.g. hearing sounds or seeing visions that are not there, or feeling confused or suffering from memory lapses)
- history of cardiovascular (i.e., heart attack), pulmonary (i.e., need for supplemental oxygen), or endocrine disease (e.g. diabetes)
- current enrollment in another study using Transcranial Magnetic Stimulation (TMS)
- current use of drugs such as amphetamines, methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or drinking 3 or more alcoholic drinks per day
- For healthy people only: chronic history of gastrointestinal symptoms (e.g., nausea, indigestion, bloating, abdominal pain)
- For CNVS people only: diagnosis of gastric motility disorder (e.g. gastroparesis/slow stomach emptying) or history of bowel obstruction (i.e., chronic partial small bowel obstruction)
The study team makes the final eligibility decision.
Where it's taking place
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.