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Compares treatment options for Type 2 Diabetes Mellitus (T2DM)
Official title The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes
ClinicalTrials.gov ID: NCT07272343
What this study is testing
What is semaglutide?
semaglutide is an investigational medicine, given as an once-weekly injection under the skin, being studied as a potential treatment for type 2 diabetes mellitus (t2dm).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- To evaluate the effects of subcutaneous injection of semaglutide for 12 weeks on patients with type 2 diabetes mellitus (T2DM), compared with concurrent energy-restricted management, on glycemic control, weight loss, inflammatory markers, liver fat content, and other parameters. The study also observed the subcutaneous and visceral fat of the participants and explored the molecular mechanisms of action, providing high-quality evidence-based support for the timing and targets of intervention in this population.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Age 18-75 years;
- BMI≥25 kg/m²;
- Diagnosed as type 2 diabetes mellitus patients according to the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2020...
- HbA1c≤8.5%;
- Duration of diabetes ≤3 months, and no use of antihyperglycemic drugs;
You likely can't join if
- BMI \< 25 kg/m²;
- Age \ 75 years;
- History of type 1 diabetes, acute pancreatitis, or diabetes secondary to pancreatectomy;
- History of bariatric surgery or planned bariatric surgery, or currently attempting weight loss within the past 3 months, or use of weight-loss...
- Use of GLP-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors, thiazolidinediones, or other related...
- Pregnant or breastfeeding women, or those planning to conceive during the study period;
See the full eligibility criteria
- Age 18-75 years;
- BMI≥25 kg/m²;
- Diagnosed as type 2 diabetes mellitus patients according to the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2020 Edition)";
- HbA1c≤8.5%;
- Duration of diabetes ≤3 months, and no use of antihyperglycemic drugs;
- Willing to participate in this study, and after full informed consent, agrees to strictly follow the treatment plan and promises to attend follow-up visits on time, and signs the informed consent form.
- BMI \< 25 kg/m²;
- Age \ 75 years;
- History of type 1 diabetes, acute pancreatitis, or diabetes secondary to pancreatectomy;
- History of bariatric surgery or planned bariatric surgery, or currently attempting weight loss within the past 3 months, or use of weight-loss medications within the past 3 months;
- Use of GLP-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors, thiazolidinediones, or other related drugs within the past 3 months;
- Pregnant or breastfeeding women, or those planning to conceive during the study period;
- Patients with severe diseases of important organ systems, such as severe cardiovascular and cerebrovascular diseases, respiratory diseases, gastrointestinal diseases, renal insufficiency, hematologic diseases...
- Personal or family history of medullary thyroid carcinoma;
- Patients with severe mental disorders or communication barriers that prevent accurate understanding of the study content and compliance with the trial procedures.
The study team makes the final eligibility decision.
Where it's taking place
- Jiangxi, Nanchang, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Jiangxi, Nanchang, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.