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New treatment option for Postoperative Pain, Acute
Official title Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients
ClinicalTrials.gov ID: NCT07271849
What this study is testing
What is Nalbuphine Hydrochloride injection was administered during anesthesia induction.?
Nalbuphine Hydrochloride injection was administered during anesthesia induction. is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for postoperative pain, acute.
Also referred to as Nalbuphine.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and cerebral damage in patients.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 to 90
You may be able to join if
- All study participants voluntarily enrolled in the trial and provided written informed consent after being fully informed of the trial's purpose and...
- Participants underwent unilateral total knee arthroplasty under general anesthesia
- Elderly participants (age ≥ 65 years), regardless of gender
- Body mass index (BMI) ranging from 18 kg/m² to 30 kg/m²
- Absence of psychiatric disorders, normal consciousness, and ability to communicate effectively
You likely can't join if
- Study participants with uncontrolled or untreated hypertension (resting systolic/diastolic blood pressure \>180/100 mmHg)
- Individuals with severe respiratory diseases
- people with abnormal liver or renal function (ALT and/or AST \>2.5 times the upper limit of normal, total bilirubin \>1.5 times the upper limit of...
- Individuals with a history of drug abuse, illicit drug use, or alcohol abuse, where alcohol abuse is defined as an average daily alcohol intake...
See the full eligibility criteria
- All study participants voluntarily enrolled in the trial and provided written informed consent after being fully informed of the trial's purpose and significance
- Participants underwent unilateral total knee arthroplasty under general anesthesia
- Elderly participants (age ≥ 65 years), regardless of gender
- Body mass index (BMI) ranging from 18 kg/m² to 30 kg/m²
- Absence of psychiatric disorders, normal consciousness, and ability to communicate effectively
- American Society of Anesthesiologists (ASA) physical status classification I-III;
- No contraindications to the study medications
- Study participants with uncontrolled or untreated hypertension (resting systolic/diastolic blood pressure \>180/100 mmHg)
- Individuals with severe respiratory diseases
- people with abnormal liver or renal function (ALT and/or AST \>2.5 times the upper limit of normal, total bilirubin \>1.5 times the upper limit of normal, serum creatinine \>1.5 times the upper limit of normal)
- Individuals with a history of drug abuse, illicit drug use, or alcohol abuse, where alcohol abuse is defined as an average daily alcohol intake exceeding 2 units (1 unit = 360 mL of beer, 45 mL of 40% alcohol by volume...
The study team makes the final eligibility decision.
Where it's taking place
- Jinan, Shandong, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Jinan, Shandong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.