BridgeMD
New treatment option for Misophonia
Official title Propranolol for Misophonia
ClinicalTrials.gov ID: NCT07271485
What this study is testing
What is propranolol?
propranolol is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for misophonia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse emotional and physical symptoms triggered by misophonia. The secondary goals of this study are: 1.
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Age 18-65.
- Able to complete study visit(s) in Littleton, CO.
- Able to give informed consent.
- Participant reports clinically significant misophonia symptoms, as determined by answers on the standardized "Misophonia Trigger Screening Questions...
- A-MISO-S rating scale severity criterion: Participants must score at least a moderate ("2") or higher on question 2 and question 3 of the Amsterdam...
You likely can't join if
- Current use of scheduled propranolol for any condition.
- Any of the known contraindications for taking propranolol:
- cardiogenic shock
- sinus bradycardia (\<50 bpm)
- greater than first degree heart block
- BP below 90/60
See the full eligibility criteria
- Age 18-65.
- Able to complete study visit(s) in Littleton, CO.
- Able to give informed consent.
- Participant reports clinically significant misophonia symptoms, as determined by answers on the standardized "Misophonia Trigger Screening Questions for Participants" form (described separately in the protocol)...
- A-MISO-S rating scale severity criterion: Participants must score at least a moderate ("2") or higher on question 2 and question 3 of the Amsterdam Misophonia Scale (A-MISO-S) at screening, since this indicates...
- Able to communicate misophonic distress in writing and reasonably participate in our outpatient clinical setting, meaning able to tolerate being in this outpatient clinical setting, follow the clinic rules for all...
- Must agree to follow study clinician advice and seek additional care outside of this clinic if advised (e.g., if advised to seek help from emergency services for a potentially serious adverse reaction).
- English fluency
- Current use of scheduled propranolol for any condition.
- Any of the known contraindications for taking propranolol:
- cardiogenic shock
- sinus bradycardia (\<50 bpm)
- greater than first degree heart block
- BP below 90/60
- asthma / bronchial asthma that requires treatment or medication, and/or has caused clinical concerns within the last 5 years
- Other heart conditions that require ongoing medical treatment
- Participants with any of the following relative contraindications for taking propranolol:
- participants who have active anorexia, purging, or who are underweight (\<18.5 BMI)
- Active drug or alcohol use within the last 48 hours prior to study participation, or active drug withdrawals
- A history of untreated diabetes or other endocrine disorders that could be harmed by exposure to propranolol
- history of cardiovascular disease or stroke, or symptomatic blood disorders such as anemia
- history of any other severe physical or neurological conditions that may affect their ability to participate in the study
- Participants with liver or kidney disease that would be affect or be affected by the study drug
- Participants may, depending on the circumstances as decided by the study clinician, be excluded for any of the following conditions that may have adverse reactions to propranolol, including: Raynaud disease or other...
- Participants taking any other medications that could interfere with the effects of propranolol, as determined by the study clinician (e.g. other beta blockers, alpha blockers,prazosin, clonidine, guanfacine, diuretics...
- Allergy or sensitivity to propranolol, placebo ingredients, and/or capsule ingredients.
- Pregnant or nursing.
- Any of the following in 30 days prior to enrollment: active psychosis, suicidal/ self-harming / homicidal thoughts, bipolar mania, panic attacks, traumatic dissociation, Post-Traumatic Stress Disorder (PTSD) flashbacks...
- Participant self-reports or clinical interview identifies any misophonia-triggered reactions within the past year that posed a significant risk to health or safety, including suicidal or homicidal ideation, or...
- Misophonia trigger symptoms are determined by a medical provider to be better explained by a condition other than Misophonia, such as hyperacusis or phonophobia.
- Inability to hear routine sounds and communication (ie severe hearing impairment), only if it interferes with ability to hear the misophonia triggers on the video.
- Participants who are triggered by the sound of water running or a car alarm (our control videos)
The study team makes the final eligibility decision.
Where it's taking place
- Littleton, Colorado, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Littleton, Colorado, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.