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New treatment option for Pancreatic Cancer
Official title A Study of Multiparametric Ultrasound Imaging Methods
ClinicalTrials.gov ID: NCT07270237
What this study is testing
- What it's testing
- The researchers are doing this study to see how well a type of ultrasound imaging called multiparametric ultrasound (mpUS), can be used to examine, evaluate, and provide information about different cancerous and non-cancerous tissue. The researchers will compare the results of mpUS imaging to standard ultrasound imaging and other standard tests.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Cohort 1 - Feasibility of multiparametric endoscopic ultrasound (mpEUS) imaging of patients at high-risk for pancreatic cancer: Patient Group: those...
- 10 years younger than the earliest pancreatic cancer diagnosis in the family
- Be at least 50 years old
- Be at least 40 years old if diagnosed with FAMMM syndrome (CDKN2A/p16) or Hereditary Pancreatitis (PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate...
- Be at least 35 years old if diagnosed with Peutz-Jeghers syndrome (STK11 aka LKB1)
You likely can't join if
- Cohort 2 - Multiparametric endoscopic ultrasound imaging (mpEUS) of patients with pancreatic ductal adenocarcinoma:
- Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
- Under 18 years of age Cohort 3 -Thyroid nodule assessment with multiparametric ultrasound (mpUS) imaging
- Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
- Under 18 years of age
See the full eligibility criteria
- Cohort 1 - Feasibility of multiparametric endoscopic ultrasound (mpEUS) imaging of patients at high-risk for pancreatic cancer: Patient Group: those having standard endoscopic ultrasounds because they are at high risk...
- 10 years younger than the earliest pancreatic cancer diagnosis in the family
- Be at least 50 years old
- Be at least 40 years old if diagnosed with FAMMM syndrome (CDKN2A/p16) or Hereditary Pancreatitis (PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate hereditary pancreatitis genes)
- Be at least 35 years old if diagnosed with Peutz-Jeghers syndrome (STK11 aka LKB1)
- Not pregnant and not Nursing
- Relatives at least 21 years old with other high-risk clinical criteria that warrants pancreatic cancer surveillance or follow-up as determined by the project leader (Dr. Vineet Rolston)
- Must agree to be contacted for follow-up
- Must satisfy at least one of the following 4 criteria:
- Have at least two affected relatives who are a first-degree relative to each other, of whom at least one is a first degree relative to the individual OR have at least two affected first-degree relatives on the same side...
- Have at least one first- or second-degree affected relative and have germline genetic test results that confirm a likely pathogenic or pathogenic variant in at least one of the following genes:
- APC (Familial Adenomatous Polyposis (FAP) and Attenuated FAP syndrome
- BRCA1(Hereditary Breast and Ovarian Cancer Symptoms)
- MLH1, MSH2, MSH6, PMS2, or EPCAM (Lynch Syndrome)
- PALB2
- TP53 (Li-Fraumeni Syndrome)
- Other established pancreatic cancer predisposition gene per project leader's discretion
- Have germline genetic test results that confirm a likely pathogenic or pathogenic variant in one or more of the following genes:
- CDKN2A/p16 (Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM))
- STK11 aka LKB1 (Peutz-Jeghers Syndrome)
- PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate hereditary pancreatitis genes per project leader's discretion
- ATM (ataxia telangiectasia mutated)
- BRCA 2(Hereditary Breast and Ovarian Cancer Symptoms)
- Relatives at least 21 years old with other high-risk clinical criteria that warrants pancreatic cancer surveillance or follow-up as determined the project leader (Dr. Vineet Rolston) Cohort 2 - Multiparametric...
- Patients with pancreatic ductal adenocarcinoma
- Are undergoing endoscopic ultrasound-guided tissue core biopsy as part of their standard of care
- Not pregnant and not nursing Cohort 3 - Thyroid nodule assessment with multiparametric ultrasound (mpUS) imaging: Patient Group: those with a thyroid nodule that will be biopsied whether they have known cancer or not
- Are undergoing ultrasound-guided thyroid biopsy as part of their standard of care
- Not pregnant and not nursing Healthy Volunteers will be entered into the study if they meet the following criteria:
- No known cancer diagnosis or thyroid nodules
- Age ≥ 18
- Able to understand and give informed consent
- Not pregnant and not nursing
- Cohort 2 - Multiparametric endoscopic ultrasound imaging (mpEUS) of patients with pancreatic ductal adenocarcinoma:
- Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
- Under 18 years of age Cohort 3 -Thyroid nodule assessment with multiparametric ultrasound (mpUS) imaging
- Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
- Under 18 years of age
The study team makes the final eligibility decision.
Where it's taking place
- Basking Ridge, New Jersey, United States
- Middletown, New Jersey, United States
- Montvale, New Jersey, United States
- Commack, New York, United States
- Harrison, New York, United States
- New York, New York, United States
- Uniondale, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Basking Ridge, New Jersey, United States; Middletown, New Jersey, United States; Montvale, New Jersey, United States; Commack, New York, United States; Harrison, New York, United States; New York, New York, United States and 1 more location(s). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.