BridgeMD
Tests treatment safety and results for Cirrhoses, Liver
Official title Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial
ClinicalTrials.gov ID: NCT07267260
What this study is testing
What is Vonoprazan 20 mg?
Vonoprazan 20 mg is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for cirrhoses, liver.
Also referred to as Potassium-competitive acid blocker, TAK-438.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn if the medicine vonoprazan can help prevent ulcers that may develop after endoscopic variceal band ligation (EVBL) in adults with liver cirrhosis. These ulcers sometimes cause pain or delayed bleeding after the procedure.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Adults aged 18 to 75 years (male or female)
- Diagnosis of liver cirrhosis confirmed by clinical, biochemical, or imaging findings.
- Presence of documented esophageal varices requiring endoscopic variceal band ligation (EVBL).
- Able and willing to provide written informed consent in English or Urdu.
- Willing to comply with study procedures, including taking study medication and attending follow-up endoscopy.
You likely can't join if
- History of gastric or esophageal surgery
- Allergy or contraindication to vonoprazan or study drug components
- Pregnant or lactating women
- Individuals who are non-cooperative or unable to understand local languages
- Critically ill patients, including: ICU admission Requirement for mechanical ventilation GCS \< 10
- Active gastrointestinal bleeding at the time of enrollment
See the full eligibility criteria
- Adults aged 18 to 75 years (male or female)
- Diagnosis of liver cirrhosis confirmed by clinical, biochemical, or imaging findings.
- Presence of documented esophageal varices requiring endoscopic variceal band ligation (EVBL).
- Able and willing to provide written informed consent in English or Urdu.
- Willing to comply with study procedures, including taking study medication and attending follow-up endoscopy.
- History of gastric or esophageal surgery
- Allergy or contraindication to vonoprazan or study drug components
- Pregnant or lactating women
- Individuals who are non-cooperative or unable to understand local languages
- Critically ill patients, including: ICU admission Requirement for mechanical ventilation GCS \< 10
- Active gastrointestinal bleeding at the time of enrollment
- Malignancy of the upper gastrointestinal tract
The study team makes the final eligibility decision.
Where it's taking place
- Lahore, Punjab Province, Pakistan
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lahore, Punjab Province, Pakistan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.