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New treatment option for PTSD
Official title Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
ClinicalTrials.gov ID: NCT07260032
What this study is testing
- What it's testing
- The purpose of this study is to use a non-invasive imaging technique called positron emission tomography/magnetic resonance imaging (PET/MRI) to investigate the effects of exercise on brain activity and arterial (blood vessel) inflammation in people with PTSD symptoms and evidence of or elevated risk for artery disease.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Age 18-65 years
- Trauma exposure
- PTSD symptoms
- Subclinical atherosclerotic CVD (e.g., coronary, cerebrovascular, or peripheral arterial plaque or calcifications on imaging), clinical...
- Ability to understand and sign informed consent
You likely can't join if
- History of stroke, brain surgery, or seizure
- Use of certain CVD medications (e.g., beta-blockers, high-intensity statins [e.g., rosuvastatin 20/40 mg and atorvastatin 40/80 mg], PCSK-9...
- Psychiatric or cardiovascular medication change within 4 weeks (i.e., stable regimen is allowed)
- Unstable blood pressure or cardiac arrhythmia
- Currently in a supervised or graduated exercise program
- Neurological or systemic inflammatory disease/current systemic anti-inflammatory therapy
See the full eligibility criteria
- Age 18-65 years
- Trauma exposure
- PTSD symptoms
- Subclinical atherosclerotic CVD (e.g., coronary, cerebrovascular, or peripheral arterial plaque or calcifications on imaging), clinical atherosclerotic CVD (e.g., myocardial infarction or revascularization), or...
- Ability to understand and sign informed consent
- History of stroke, brain surgery, or seizure
- Use of certain CVD medications (e.g., beta-blockers, high-intensity statins [e.g., rosuvastatin 20/40 mg and atorvastatin 40/80 mg], PCSK-9 inhibitors)
- Psychiatric or cardiovascular medication change within 4 weeks (i.e., stable regimen is allowed)
- Unstable blood pressure or cardiac arrhythmia
- Currently in a supervised or graduated exercise program
- Neurological or systemic inflammatory disease/current systemic anti-inflammatory therapy
- Moderate/severe alcohol/substance use disorder
- Current mania/psychosis
- Weight \>300 lbs.
- Claustrophobia
- Pregnancy
- Metal implants
- Uncontrolled hyperglycemia (HgbA1c\>7.5%)
- people who have had significant radiation exposure as part of research (\>2 nuclear tests, computed tomography images, or fluoroscopic procedures) during the preceding 12-months
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.