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New treatment option for Chronic Kidney Disease
Official title Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure
ClinicalTrials.gov ID: NCT07259512
What this study is testing
What is Ramipril?
Ramipril is an investigational medicine, given as an once-daily, being studied as a potential treatment for chronic kidney disease.
Also referred to as ACE inhibitor.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study compares the effects of once-daily versus twice-daily ramipril dosing on renal function in chronic kidney disease (CKD) patients with heart failure with reduced ejection fraction (HFrEF). Outcomes include changes in plasma renin activity, malondialdehyde, interleukin-6, albuminuria, and cystatin C after 30 days of therapy.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Female or Male with age \>18 years old
- Patients with a diagnosis of CKD stage 3-5 non-dialysis with low ejection fraction heart failure (ejection fraction \< 40%)
You likely can't join if
- Receiving hemodialysis therapy
- History of intolerance to ACE inhibitors
- Refractory hyperkalemia
- Pregnancy
- History of angioedema to ACE inhibitors
- Receiving sacubitril-valsartan therapy
See the full eligibility criteria
- Female or Male with age \>18 years old
- Patients with a diagnosis of CKD stage 3-5 non-dialysis with low ejection fraction heart failure (ejection fraction \< 40%)
- Receiving hemodialysis therapy
- History of intolerance to ACE inhibitors
- Refractory hyperkalemia
- Pregnancy
- History of angioedema to ACE inhibitors
- Receiving sacubitril-valsartan therapy
- Receiving ARB therapy
- Hypotension with blood pressure \<90/60, or patients in shock.
The study team makes the final eligibility decision.
Where it's taking place
- Kartasura, Central Java, Indonesia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kartasura, Central Java, Indonesia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.