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New treatment option for Type 2 Diabetes Mellitus MeSH:D003924
Official title Non-surgical Periodontal Therapy and Kidney Outcomes in Type 2 Diabetes Mellitus
ClinicalTrials.gov ID: NCT07256613
What this study is testing
- What it's testing
- Brief Summary (Lay Description) This research study is being conducted to understand whether treating gum disease (periodontitis) can help improve kidney health in patients who have type-2 diabetes mellitus (T2DM). Both diabetes and gum disease are common long-term conditions that often occur together.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 65
You may be able to join if
- Adults between 30 and 65 years of age.
- Men and women previously diagnosed with type 2 diabetes mellitus for at least one year.
- Participants with uncontrolled diabetes, defined as HbA1c ≥ 7%.
- Presence of moderate to severe gum disease (Stage II or Stage III periodontitis) as determined by a dental examination.
- Estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73 m² or higher.
You likely can't join if
- Critically ill individuals or those unable to communicate effectively.
- Pregnant or breastfeeding women.
- Women currently using hormone replacement therapy or oral contraceptives within the past six months.
- Individuals taking steroidal, nonsteroidal anti-inflammatory drugs (NSAIDs), or other anti-inflammatory medications within the past three months...
- Participants with a recent history of major blood loss, trauma, or gastrointestinal bleeding.
- Use of antibiotics within the last month.
See the full eligibility criteria
- Adults between 30 and 65 years of age.
- Men and women previously diagnosed with type 2 diabetes mellitus for at least one year.
- Participants with uncontrolled diabetes, defined as HbA1c ≥ 7%.
- Presence of moderate to severe gum disease (Stage II or Stage III periodontitis) as determined by a dental examination.
- Estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73 m² or higher.
- Willing and able to provide written informed consent.
- Critically ill individuals or those unable to communicate effectively.
- Pregnant or breastfeeding women.
- Women currently using hormone replacement therapy or oral contraceptives within the past six months.
- Individuals taking steroidal, nonsteroidal anti-inflammatory drugs (NSAIDs), or other anti-inflammatory medications within the past three months (except low-dose aspirin up to 75 mg daily).
- Participants with a recent history of major blood loss, trauma, or gastrointestinal bleeding.
- Use of antibiotics within the last month.
- History of fever or vomiting lasting more than one week within the last month.
- Regular tobacco or alcohol users.
- Individuals with any other chronic disease or condition that could interfere with study outcomes.
- Individuals unwilling or unable to comply with study procedures or follow-up visits.
The study team makes the final eligibility decision.
Where it's taking place
- Karachi, Sindh, Pakistan
Compensation & support
Some study costs may be covered.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Karachi, Sindh, Pakistan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.