BridgeMD
Compares treatment options for Liver Cirrhosis
Official title Comparison of Underdilated Versus Standard TIPS in Preventing Variceal Rebleeding in Patients With Cirrhosis
ClinicalTrials.gov ID: NCT07253389
What this study is testing
- What it's testing
- Transjugular intrahepatic portosystemic shunt (TIPS) is a key therapeutic intervention for complications of portal hypertension. However, the risk of post-procedural hepatic encephalopathy (HE) limits its broader clinical application.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- 1\. Age 18-75 years. 2. Diagnosis of liver cirrhosis according to the 2023 Consensus Opinion on the Clinical Diagnosis and Treatment of Liver...
- High-risk acute esophageal or type 1 gastroesophageal variceal bleeding, including: Child-Pugh grade B with a score \> 7 and endoscopic evidence of...
- Hepatic venous pressure gradient (HVPG) \> 20 mmHg during bleeding.
- Early rebleeding within 5 days.
- Bleeding uncontrolled despite pharmacological and endoscopic therapy. 4. History of esophageal or gastric variceal bleeding with failure of standard...
You likely can't join if
- Budd-Chiari syndrome or other causes of non-cirrhotic portal hypertension.
- Current or prior malignancy, including hepatocellular carcinoma or malignancies of other organs.
- Complete thrombosis of the main portal vein.
- Severe psychiatric or neurologic disorders (e.g., uncontrolled epilepsy, dementia).
- Prior liver resection or liver transplantation.
- Prior TIPS or surgical portosystemic shunt.
See the full eligibility criteria
- 1\. Age 18-75 years. 2. Diagnosis of liver cirrhosis according to the 2023 Consensus Opinion on the Clinical Diagnosis and Treatment of Liver Cirrhosis in China (Chinese Society of Gastroenterology). Diagnosis is based...
- High-risk acute esophageal or type 1 gastroesophageal variceal bleeding, including: Child-Pugh grade B with a score \> 7 and endoscopic evidence of active bleeding; Child-Pugh grade C with a score \< 14.
- Hepatic venous pressure gradient (HVPG) \> 20 mmHg during bleeding.
- Early rebleeding within 5 days.
- Bleeding uncontrolled despite pharmacological and endoscopic therapy. 4. History of esophageal or gastric variceal bleeding with failure of standard first-line treatment [endoscopy combined with non-selective...
- Budd-Chiari syndrome or other causes of non-cirrhotic portal hypertension.
- Current or prior malignancy, including hepatocellular carcinoma or malignancies of other organs.
- Complete thrombosis of the main portal vein.
- Severe psychiatric or neurologic disorders (e.g., uncontrolled epilepsy, dementia).
- Prior liver resection or liver transplantation.
- Prior TIPS or surgical portosystemic shunt.
- Pregnancy or lactation.
- Any contraindication to TIPS, including: (1) Congestive heart failure (New York Heart Association class C or D, or left ventricular ejection fraction \ 45 mmHg as measured invasively). (3) Uncontrolled systemic...
The study team makes the final eligibility decision.
Where it's taking place
- Xi'an, Shaanxi, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Xi'an, Shaanxi, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.