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New treatment option for Nicotine Dependence
Official title Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Undergoing Thoracic Surgery: A Randomized Controlled Pilot Study
ClinicalTrials.gov ID: NCT07250230
What this study is testing
What is Nicotine patch?
Nicotine patch is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for nicotine dependence.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Globally, approximately 230 million adults undergo surgical procedures each year, with around 30% of patients maintaining smoking habits prior to surgery. Extensive clinical research has confirmed that tobacco exposure is a significant independent risk factor for perioperative complications.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75, men only
You may be able to join if
- Male, aged 18-75 years, with a body mass index (BMI) of 18-28 kg/m2 Between;
- Thoracoscopic lobectomy/segmental/wedge resection under general anesthesia;
- American Society of Anesthesiologists (ASA) classifications I-III Level;
- Regular smoking for more than 2 years, smoking more than 10 cigarettes per day in the past 6 months, and not successfully quitting smoking within 1...
- No severe respiratory diseases, no serious cardiovascular and cerebrovascular diseases (hypertension is treated with SBP ≤ 160mmHg, DBP ≤ 90mmHg...
You likely can't join if
- Those who have a history of alcoholism, long-term use of sedatives or analgesics;
- Patients with psychiatric and nervous system diseases (such as Parkinson's, depression, schizophrenia) and severe audio-visual dysfunction before...
- Preoperative systolic blood pressure \> 180mmHg or diastolic blood pressure \> 110mmHg;
- Patients who were converted to thoracotomy during thoracoscopic surgery
- Patients who are transferred to the intensive care unit after surgery;
- Patients who refuse to use analgesic pump treatment/do not configure the analgesic pump according to regulations;
See the full eligibility criteria
- Male, aged 18-75 years, with a body mass index (BMI) of 18-28 kg/m2 Between;
- Thoracoscopic lobectomy/segmental/wedge resection under general anesthesia;
- American Society of Anesthesiologists (ASA) classifications I-III Level;
- Regular smoking for more than 2 years, smoking more than 10 cigarettes per day in the past 6 months, and not successfully quitting smoking within 1 month (after admission, the doctor and nurse informed the smoking...
- No severe respiratory diseases, no serious cardiovascular and cerebrovascular diseases (hypertension is treated with SBP ≤ 160mmHg, DBP ≤ 90mmHg after systemic treatment);
- Obtain informed consent.
- Those who have a history of alcoholism, long-term use of sedatives or analgesics;
- Patients with psychiatric and nervous system diseases (such as Parkinson's, depression, schizophrenia) and severe audio-visual dysfunction before surgery;
- Preoperative systolic blood pressure \> 180mmHg or diastolic blood pressure \> 110mmHg;
- Patients who were converted to thoracotomy during thoracoscopic surgery
- Patients who are transferred to the intensive care unit after surgery;
- Patients who refuse to use analgesic pump treatment/do not configure the analgesic pump according to regulations;
- Patients who have self-removed patches/short hospital stay resulting in a postoperative observation time of \< 48 hours
The study team makes the final eligibility decision.
Where it's taking place
- Zhengzhou, Henan, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Zhengzhou, Henan, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.