BridgeMD
New treatment option for Intracerebral Hemorrhage
Official title Non-invasive Ultrasound and Hematoma Clearance After Intracerebral Hemorrhage
ClinicalTrials.gov ID: NCT07246473
What this study is testing
- What it's testing
- Intracerebral hemorrhage (ICH) is one of the stroke subtypes with the highest global rates of disability and mortality, accounting for 15%-20% of all strokes. Currently, there is a lack of evidence-based interventions for ICH, with treatment primarily relying on supportive care.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Age 18 to 80 years;
- Spontaneous intracerebral hemorrhage (ICH);
- Supratentorial ICH;
- Hematoma volume \<30 mL (calculated using the ABC/2 method);
- Glasgow Coma Scale (GCS) score \>9 at randomization;
You likely can't join if
- Intracerebral hemorrhage attributed to other causes (e.g., cerebral aneurysm, cerebrovascular malformation, brain tumor, cerebral venous sinus...
- Hemorrhage located in the infratentorial region.
- Hemorrhage confined primarily to the ventricular system.
- Clinical signs or symptoms suggestive of brain herniation (e.g., progressive decline in level of consciousness, diminished or absent pupillary light...
- Severe cardiac dysfunction (NYHA Class III or IV).
- High-risk chronic arrhythmias (e.g., sick sinus syndrome, second- or third-degree atrioventricular block, bradycardia-related syncope without...
See the full eligibility criteria
- Age 18 to 80 years;
- Spontaneous intracerebral hemorrhage (ICH);
- Supratentorial ICH;
- Hematoma volume \<30 mL (calculated using the ABC/2 method);
- Glasgow Coma Scale (GCS) score \>9 at randomization;
- Time from onset to randomization: 48-72 hours;
- Patient and/or legal representative provides informed consent.
- Intracerebral hemorrhage attributed to other causes (e.g., cerebral aneurysm, cerebrovascular malformation, brain tumor, cerebral venous sinus thrombosis, hemorrhagic transformation of ischemic stroke, head trauma...
- Hemorrhage located in the infratentorial region.
- Hemorrhage confined primarily to the ventricular system.
- Clinical signs or symptoms suggestive of brain herniation (e.g., progressive decline in level of consciousness, diminished or absent pupillary light reflexes, bilateral pyramidal signs).
- Severe cardiac dysfunction (NYHA Class III or IV).
- High-risk chronic arrhythmias (e.g., sick sinus syndrome, second- or third-degree atrioventricular block, bradycardia-related syncope without pacemaker implantation).
- Severe hepatic impairment defined as ALT \>2x ULN or AST \>2x ULN (ULN = Upper Limit of Normal).
- Severe renal impairment defined as serum creatinine \>1.5x ULN.
- History of severe asthma or chronic obstructive pulmonary disease (COPD).
- History of coagulopathy or systemic bleeding disorder.
- Leukopenia (\<2 × 10⁹/L) or thrombocytopenia (\<100 × 10⁹/L).
- Patients scheduled for surgical intervention (including, but not limited to, hematoma evacuation [minimally invasive or conventional], decompressive craniectomy, hematoma aspiration, or external ventricular drainage)...
- Pre-stroke modified Rankin Scale (mRS) score \>2.
- Presence of other severe disease resulting in a life expectancy of less than 1 year.
- Inability to understand the study procedures and/or complete follow-up due to psychiatric illness, cognitive impairment, or emotional disorders.
- Women who are pregnant or lactating.
- Participation in another clinical trial within the past 3 months or current participation in another clinical trial.
The study team makes the final eligibility decision.
Where it's taking place
- Wuhu, Anhui, China
- Beijing, Beijing Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wuhu, Anhui, China; Beijing, Beijing Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.