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New treatment option for Adverse Childhood Experience
Official title Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
ClinicalTrials.gov ID: NCT07244809
What this study is testing
- What it's testing
- Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction. Greater exposure to ACEs are associated with greater increases in the risk of cardiovascular diseases and death.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 29. Healthy volunteers may be eligible.
You may be able to join if
- 18-29 years
- ACE score \>=4
You likely can't join if
- Resting arterial blood pressure \>140/90 mmHg
- BMI \ = 35
- Are on a weight-loss diet or involved in a formal weight-loss program or are not intentionally weight stable for 6 months (+/- 5 kg) prior to the...
- Cardiovascular or metabolic prescription drug use
- Vasoactive antidepressant drug use (SSRIs and clonidine)
- Current heavy alcohol use, as defined as binge drinking on 5 or more days in the last month, or consuming more than 7 (women) or 14 (men) drinks per...
See the full eligibility criteria
- 18-29 years
- ACE score \>=4
- Resting arterial blood pressure \>140/90 mmHg
- BMI \ = 35
- Are on a weight-loss diet or involved in a formal weight-loss program or are not intentionally weight stable for 6 months (+/- 5 kg) prior to the study.
- Cardiovascular or metabolic prescription drug use
- Vasoactive antidepressant drug use (SSRIs and clonidine)
- Current heavy alcohol use, as defined as binge drinking on 5 or more days in the last month, or consuming more than 7 (women) or 14 (men) drinks per week in the last month (per NIAAA definition)
- Current or recent (within the last 6 mo.) illicit drug use disorder as indicated by a score of 3 or greater on the Drug Abuse Screening Test (DAST-10)
- Current tobacco or nicotine use
- Vaping
- Regular vigorous (\>6 METs) aerobic exercise (\>4 bouts/week, \>30 min/bout)
- dietary supplementation with antioxidants or habitual use of NSAIDs
- Currently pregnant or breastfeeding
The study team makes the final eligibility decision.
Where it's taking place
- Iowa City, Iowa, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 29 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Iowa City, Iowa, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.