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New treatment option for Postoperative Pain
Official title Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery
ClinicalTrials.gov ID: NCT07244029
What this study is testing
What is Escin?
Escin is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for postoperative pain.
Also referred to as Reparil®-Dragees.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of impacted mandibular third molars. A total of 100 participants aged 18-40 years will be enrolled at the Dental Center, Medical City Hospital for Military and Security Services (MCMSS), Al Khoud, Oman.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Patients indicated for surgical removal of impacted mandibular third molars according to National Institute for Health and Care Excellence (NICE)...
- Age between 18 and 40 years.
- Impacted mandibular third molars with similar anatomical position and difficulty level as classified by Pell and Gregory and Pederson scoring.
- Healthy individuals (ASA I-II) with no significant systemic illness.
- Willing to provide written informed consent and attend all follow-up visits (Day 2 and Day 7 post-surgery).
You likely can't join if
- Recent use (within three weeks preoperatively) of anti-inflammatories, corticosteroids, or antibiotics.
- Known allergies or hypersensitivity to Aescin, Ibuprofen, rescue medications, or local anesthetics.
- Pregnant or lactating women.
- Patients with contraindications to NSAIDs (e.g., asthma, bleeding disorders, chronic kidney disease, active peptic ulcer, or cardiovascular disease).
- Recent use of substances that may affect surgery or interact with study drugs (e.g., contraceptives, alcohol, or tobacco).
- Surgical time exceeding 30 minutes or cases with intraoperative complications requiring non-study medications.
The study team makes the final eligibility decision.
Where it's taking place
- Muscat, Al Khoud, Oman
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Muscat, Al Khoud, Oman. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.