BridgeMD
New treatment option for Role of the Noradrenergic System in the Regulation of Learning Dynamics
Official title Role of the Noradrenergic System in the Regulation of Learning Dynamics: Evaluation of the Effect of a Low-dose Selective Noradrenaline Reuptake Inhibitor (NOISYXETINE)
ClinicalTrials.gov ID: NCT07239791
What this study is testing
What is Atomoxetine?
Atomoxetine is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for role of the noradrenergic system in the regulation of learning dynamics.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Administration of low-dose selective noradrenaline reuptake inhibitor (sNRI) (e.g. atomoxetine) to healthy subjects is a validated model of increasing cortical noradrenaline levels which, combined with computational modelling of behaviour, allows fine-grained analysis of the impact on learning processes of noradrenaline's fluctuations in the human cortex.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 39. Healthy volunteers may be eligible.
You may be able to join if
- Right-handed, assessed by the Edinburgh scale;
- Written signed informed consent;
- Subject covered by a social security regimen.
You likely can't join if
- Pregnant, parturient or breastfeeding woman;
- First-degree family history of axis I disorder (DSM-IV-TR), excepted unipolar mood and anxiety disorders with OCD;
- Personal history of axis I disorder (DSM-IV-TR) in the 6 months preceding the study entry;
- Dependence on a psychoactive substance in the 12 months preceding the study entry, excluding nicotine, any behavioural disorder incompatible with a...
- Neuro/psychotropic treatment ongoing or stopped less than 1 month ago;
- Personal history of neurological pathology (e.g.: congenital malformation, benign or malignant tumour, degenerative disease of the central nervous...
See the full eligibility criteria
- Right-handed, assessed by the Edinburgh scale;
- Written signed informed consent;
- Subject covered by a social security regimen.
- Pregnant, parturient or breastfeeding woman;
- First-degree family history of axis I disorder (DSM-IV-TR), excepted unipolar mood and anxiety disorders with OCD;
- Personal history of axis I disorder (DSM-IV-TR) in the 6 months preceding the study entry;
- Dependence on a psychoactive substance in the 12 months preceding the study entry, excluding nicotine, any behavioural disorder incompatible with a 2-hour electroencephalographic recording;
- Neuro/psychotropic treatment ongoing or stopped less than 1 month ago;
- Personal history of neurological pathology (e.g.: congenital malformation, benign or malignant tumour, degenerative disease of the central nervous system (CNS), epilepsy, inflammatory or infectious disease of the CNS...
- Personal history of chronic disease of infectious, neoplastic, vascular, dysimmune or inflammatory, metabolic or endocrine, degenerative or genetic aetiology. In particular, angle-closure glaucoma, pheochromocytoma...
- Any medical treatment in the month preceding the study entry, apart from effective contraceptive treatment;
- Subject deprived of liberty by a judicial or administrative decision;
- Person subject to a legal protection measure or unable to express consent;
- Known intolerance to atomoxetine;
- Need to wear glasses and/or lenses to obtain normal vision;
- Subject in an exclusion period or enrolled in an treatment study.
The study team makes the final eligibility decision.
Where it's taking place
- Paris, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 39 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Paris, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.