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New treatment option for PARKINSON DISEASE (Disorder)
Official title Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease
ClinicalTrials.gov ID: NCT07226284
What this study is testing
- What it's testing
- This study is designed to better understand the mechanisms contributing to impaired activation of leg muscles in people with Parkinson's disease (PD) and to test if stimulation of a nerve at the neck can improve muscle activation, walking and balance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 76. Healthy volunteers may be eligible.
You may be able to join if
- Diagnosis of idiopathic Parkinson's disease,
- On stable medication for the preceding month and anticipated over the next 3 months,
- Able to ambulate without the use of an assistive device for more than 50 meters. Control Cohort:
- Age (± 3 years) and sex distribution matched to the PD cohort,
- Able to ambulate without the use of an assistive device for more than 50 meters.
You likely can't join if
- Failure to demonstrate capacity to consent (based on UBACC and/or MacArthur-CR),
- History of significant neurological disorder (besides PD in the PD group),
- History of stroke, traumatic brain injury, intracranial aneurysm, intracranial hemorrhage, brain tumor or atypical parkinsonian disorder,
- Severe orthopedic or other related musculoskeletal pathology that has significant adverse effects on gait,
- Women who are pregnant or may be pregnant,
- Insufficient comprehension of the English language,
See the full eligibility criteria
- Diagnosis of idiopathic Parkinson's disease,
- On stable medication for the preceding month and anticipated over the next 3 months,
- Able to ambulate without the use of an assistive device for more than 50 meters. Control Cohort:
- Age (± 3 years) and sex distribution matched to the PD cohort,
- Able to ambulate without the use of an assistive device for more than 50 meters.
- Failure to demonstrate capacity to consent (based on UBACC and/or MacArthur-CR),
- History of significant neurological disorder (besides PD in the PD group),
- History of stroke, traumatic brain injury, intracranial aneurysm, intracranial hemorrhage, brain tumor or atypical parkinsonian disorder,
- Severe orthopedic or other related musculoskeletal pathology that has significant adverse effects on gait,
- Women who are pregnant or may be pregnant,
- Insufficient comprehension of the English language,
- History of substance abuse in past 2 years; Additional exclusion criteria for VNS experiment
- Pain at the nVNS treatment site (e.g., dysesthesia, neuralgia, cervicalgia);
- Lesion (including lymphadenopathy), previous surgery (including carotid endarterectomy or vascular neck surgery) or abnormal anatomy at the stimulation site (open wound, rash, infection, swelling, cut, sore, drug patch...
- Known or suspected severe atherosclerotic cardiovascular disease, severe carotid artery disease (e.g., bruits or history of TIA or stroke), congestive heart failure, known severe coronary artery disease or prior...
- Abnormal baseline electrocardiogram (ECG) within the last year (e.g., second or third-degree heart block, prolonged QT interval, atrial fibrillation, atrial flutter, history of ventricular tachycardia or ventricular...
- Recent history of uncontrolled high blood pressure, bradycardia, tachycardia, or know recent history orthostatic hypotension;
- Previous unilateral or bilateral vagotomy;
- Implanted metal cervical spine hardware, other metallic implants or implantable medical devices such as deep brain stimulator, hearing aid implant, pacemaker, implanted cardioverter defibrillator, cranial aneurysm...
- History of syncope or seizures (within the last 2 years);
The study team makes the final eligibility decision.
Where it's taking place
- Minneapolis, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 76 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Minneapolis, Minnesota, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.