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New treatment option for Cannabis Use Disorder
Official title Sex Differences in Neurobehavioral Response to THC
ClinicalTrials.gov ID: NCT07225777
What this study is testing
What is Dronabinol?
Dronabinol is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for cannabis use disorder.
Also referred to as Marinol.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 45
You may be able to join if
- Age 21-45
- DSM-5 criteria for CUD
- Cannabis use ≥4 days/week
- THC-positive urine
- BMI 18-30
You likely can't join if
- Lifetime psychotic or bipolar disorder
- Recent drug use other than cannabis
- Current psychotropic medication
- Treatment-seeking for SUD
- Current psychiatric disorder (except mild alcohol, nicotine, or caffeine use disorder)
- Pregnancy/nursing
See the full eligibility criteria
- Age 21-45
- DSM-5 criteria for CUD
- Cannabis use ≥4 days/week
- THC-positive urine
- BMI 18-30
- Regular menstrual cycle (females)
- Willingness to use non-hormonal birth control (females)
- Lifetime psychotic or bipolar disorder
- Recent drug use other than cannabis
- Current psychotropic medication
- Treatment-seeking for SUD
- Current psychiatric disorder (except mild alcohol, nicotine, or caffeine use disorder)
- Pregnancy/nursing
- MRI contraindications
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 45 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.