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Tests treatment safety and results for Schizophrenia
Official title A Study to Evaluate the Effect of KarXT on Urological Safety
ClinicalTrials.gov ID: NCT07221877
What this study is testing
What is Xanomeline/trospium chloride?
Xanomeline/trospium chloride is an investigational medicine, being studied as a potential treatment for schizophrenia.
Also referred to as KarXT, BMS-986510.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to characterize the effect of KarXT on voiding dynamics and urological safety in participants with DSM-5 schizophrenia.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Male and Female participants (age 18 to 65 years of age, with a primary diagnosis of schizophrenia based on psychiatric evaluation (DSM-5) and...
- Participants must have a PANSS total score ≤ 80 and CGI-S score ≤ 4, at screening and baseline, and a BMI ≥18 and ≤ 40 kg/m2.
- Participants must be willing and able to discontinue all antipsychotic medications prior to the baseline visit and be willing and able to comply with...
You likely can't join if
- Participants with newly diagnosed schizophrenia, any other DSM-5 disorder diagnosed within the past 12 months, alcohol or drug use disorder within...
- Participants at risk for suicidal behavior, as well as individuals who are pregnant or breastfeeding, will be excluded from the study.
- Other protocol-defined Inclusion/Exclusion criteria apply
The study team makes the final eligibility decision.
Where it's taking place
- Little Rock, Arkansas, United States
- Bellflower, California, United States
- Garden Grove, California, United States
- Orange, California, United States
- Lauderhill, Florida, United States
- West Palm Beach, Florida, United States
- Chicago, Illinois, United States
- Las Vegas, Nevada, United States
- Marlton, New Jersey, United States
- Philadelphia, Pennsylvania, United States
- Austin, Texas, United States
- DeSoto, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Little Rock, Arkansas, United States; Bellflower, California, United States; Garden Grove, California, United States; Orange, California, United States; Lauderhill, Florida, United States; West Palm Beach, Florida, United States and 6 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.