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Official title Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
ClinicalTrials.gov ID: NCT07216755
What this study is testing
- What it's testing
- This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Healthy adults between 18 and 40 years old.
- Recreationally active (performing ≥3 hours of structured physical activity per week).
- Non-smokers for at least the past 6 months.
- Free from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical...
- Able to perform cycle ergometer exercise to volitional fatigue.
You likely can't join if
- Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).
- Current use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates...
- Smoking, vaping, or tobacco use within the past 6 months.
- Known allergy or intolerance to beetroot products or nitrates.
- Participation in another treatment research study within the past 30 days.
- Pregnant or breastfeeding women.
See the full eligibility criteria
- Healthy adults between 18 and 40 years old.
- Recreationally active (performing ≥3 hours of structured physical activity per week).
- Non-smokers for at least the past 6 months.
- Free from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history.
- Able to perform cycle ergometer exercise to volitional fatigue.
- Willing to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session.
- Able and willing to provide written informed consent and comply with all study procedures.
- Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).
- Current use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants).
- Smoking, vaping, or tobacco use within the past 6 months.
- Known allergy or intolerance to beetroot products or nitrates.
- Participation in another treatment research study within the past 30 days.
- Pregnant or breastfeeding women.
- Any orthopedic or musculoskeletal limitation preventing safe exercise testing.
- Failure to meet inclusion criteria or inability to complete familiarization and baseline testing.
The study team makes the final eligibility decision.
Where it's taking place
- Daytona Beach, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Daytona Beach, Florida, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.