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New treatment option for Mandible Fracture
Official title Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures
ClinicalTrials.gov ID: NCT07208799
What this study is testing
What is Dexamethasone?
Dexamethasone is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for mandible fracture.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The rationale of the current research is to address the limitation of existing knowledge as it is not clear which of the two drugs (Dexamethasone or Methylprednisolone) is more effective in reduction of postoperative sequelae in patient with mandibular parasymphysis fracture. This study fills the gap by providing sound evidence on the preferred steroid option to help clinicians have more data to make decisions and improve patients' health.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40
You may be able to join if
- Patients aged 18 to 40.
- Both Gender.
- Fracture less than a week old.
- Isolated mandibular parasymphysis fractures.
You likely can't join if
- 1\. Immunocompromised patients (due to increased risk of infection and complications).
- 2\. Patients experiencing acute pain from conditions such as pulpitis, abscesses, or other acute infections (to ensure that acute pain does not...
- 3\. Patients reporting hypersensitivity to steroids (to avoid adverse reactions).
- 4\. Patients taking or requiring prophylactic antibiotics or anti-inflammatory drugs before surgery (to prevent confounding effects on study...
- 5\. Patients with a history of systemic steroid administration for 15 days (as this could affect the study's outcomes).
- 6\. Patients with chronic pain problems or mental disorders (to maintain consistency in response to treatment).
See the full eligibility criteria
- Patients aged 18 to 40.
- Both Gender.
- Fracture less than a week old.
- Isolated mandibular parasymphysis fractures.
- 1\. Immunocompromised patients (due to increased risk of infection and complications).
- 2\. Patients experiencing acute pain from conditions such as pulpitis, abscesses, or other acute infections (to ensure that acute pain does not confound the study results).
- 3\. Patients reporting hypersensitivity to steroids (to avoid adverse reactions).
- 4\. Patients taking or requiring prophylactic antibiotics or anti-inflammatory drugs before surgery (to prevent confounding effects on study outcomes).
- 5\. Patients with a history of systemic steroid administration for 15 days (as this could affect the study's outcomes).
- 6\. Patients with chronic pain problems or mental disorders (to maintain consistency in response to treatment).
- 7\. Patients with comminuted fractures (to maintain consistency in fracture type).
- 8\. Pregnant or lactating women (to avoid potential risks to the fetus and nursing infant).
- 9\. Smokers who smoke at least 10 cigarettes per day for 2 years (to minimize the impact of smoking on healing and recovery).
- ria:
The study team makes the final eligibility decision.
Where it's taking place
- Multan, Punjab Province, Pakistan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Multan, Punjab Province, Pakistan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.