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New treatment option for Beta Thalassemia Transfusion Dependent
Official title Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD
ClinicalTrials.gov ID: NCT07207577
What this study is testing
- What it's testing
- The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is: is there a difference in power output at first lactate threshold between patients with transfusion-dependent β-thalassemia and control subjects during maximal incremental exercise test.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Patients aged 18 years or older
- Patients with transfusion-dependent β-thalassaemia (B0 or B+)
- Patients who have undergone blood transfusions at intervals of between 1 and 8 weeks for at least 5 years.
- Have given their free and informed written consent after being informed of the purpose of the study, its conduct and its risks.
- Be affiliated with a social security scheme.
You likely can't join if
- \- Having received a bone marrow transplant.
- History of thromboembolic disease.
- Hospitalised for cardiac decompensation in the last 12 months.
- Lack of use of limbs (amputee, paraplegic, quadriplegic)
- Unable to comply with protocol requirements for social, family or other reasons, as determined by the investigator.
- Known concomitant medical condition that could affect compliance with the protocol
See the full eligibility criteria
- Patients aged 18 years or older
- Patients with transfusion-dependent β-thalassaemia (B0 or B+)
- Patients who have undergone blood transfusions at intervals of between 1 and 8 weeks for at least 5 years.
- Have given their free and informed written consent after being informed of the purpose of the study, its conduct and its risks.
- Be affiliated with a social security scheme.
- Not participating in any other treatment studies during the duration of this study Control people must meet all of the following criteria to participate in the study:
- Subject aged 18 years or older
- Matched in age and gender to a βTTD patient included in the study.
- Declaring to be free of known acute or chronic pathologies.
- Have given their free written consent after being informed of the purpose of the study, its conduct and its risks.
- Be affiliated with a social security scheme.
- Not participate in any other treatment study during the duration of this study.
- Have 'low' or 'moderate' IPAQ results (inactive or slightly active).
- \- Having received a bone marrow transplant.
- History of thromboembolic disease.
- Hospitalised for cardiac decompensation in the last 12 months.
- Lack of use of limbs (amputee, paraplegic, quadriplegic)
- Unable to comply with protocol requirements for social, family or other reasons, as determined by the investigator.
- Known concomitant medical condition that could affect compliance with the protocol
- benefiting of enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, adults under legal protection and, finally, patients in emergency situations.
- Unable to give consent.
- Pregnant or breastfeeding women.
The study team makes the final eligibility decision.
Where it's taking place
- Chambéry, France
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Chambéry, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.