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New treatment option for Healthy Volunteers
Official title A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants
ClinicalTrials.gov ID: NCT07204418
What this study is testing
What is Xanomeline/ Trospium Chloride?
Xanomeline/ Trospium Chloride is an investigational medicine, being studied as a potential treatment for healthy volunteers.
Also referred to as BMS-986510, KarXT.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate the pharmacokinetics (PK) of xanomeline following administration of KarXT in CYP2D6 normal/extensive, intermediate, poor, and ultrarapid metabolizers.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Participant must be healthy male and female (INOCBP) participants as determined by no clinically significant deviation from normal in medical...
- Participant must be a normal/extensive, intermediate, poor, or ultrarapid CYP2D6 metabolizer.
- Participant must have body mass index (BMI) of 18.0 to 32.0 kg/m2, inclusive.
You likely can't join if
- Participants must not have evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs...
- Other protocol-defined Inclusion/Exclusion criteria apply.
The study team makes the final eligibility decision.
Where it's taking place
- Anaheim, California, United States
- Lenexa, Kansas, United States
- San Antonio, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Anaheim, California, United States; Lenexa, Kansas, United States; San Antonio, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.