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Official title Hippocampal and Frontoparietal Development and Inference
ClinicalTrials.gov ID: NCT07199907
What this study is testing
- What it's testing
- The goal of this clinical trial is to test if an intervention used to manipulate memory and inference can improve our understanding of how brain development supports these abilities in healthy adolescent and adult volunteers. The main questions it aims to answer are: (1) Do hippocampus and ventromedial prefrontal cortex shift from forming simple memories for singular experiences to more complex memories that link numerous experiences together?; (2) Does an improved ability to retrieve prior memories in parietal cortex during new learning have consequences for how those memories are organized at different ages?; and (3) Does the emerging memory control supported by ventromedial prefrontal cortex development facilitate the formation of optimally-organized memory representations?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 13 to 25. Healthy volunteers may be eligible.
You may be able to join if
- Right-handed
- Have normal or corrected to normal vision
- Have normal hearing
- Do not have contraindications for MRI
- Have no history of neurological or psychiatric disorders at initial intake
You likely can't join if
- A major medical illness or a neurological disorder, or neurological abnormality including significant head trauma (loss of consciousness \> 5 min).
- Meeting criteria for any psychiatric disorder or any prior psychiatric hospitalizations
- Intelligence scores more than 1 standard deviation below the mean on the WASI-II
- History of special education placement
- Non-native English speaker
- Prior use of psychotropic medication, except antidepressants, for longer than 1 month
See the full eligibility criteria
- Right-handed
- Have normal or corrected to normal vision
- Have normal hearing
- Do not have contraindications for MRI
- Have no history of neurological or psychiatric disorders at initial intake
- Are of normal intelligence
- Native or fluent English speaker
- A major medical illness or a neurological disorder, or neurological abnormality including significant head trauma (loss of consciousness \> 5 min).
- Meeting criteria for any psychiatric disorder or any prior psychiatric hospitalizations
- Intelligence scores more than 1 standard deviation below the mean on the WASI-II
- History of special education placement
- Non-native English speaker
- Prior use of psychotropic medication, except antidepressants, for longer than 1 month
- History of moderate to severe cannabis use disorder, via self-report
- MRI exclusions: Claustrophobia; tattoos above the shoulders; permanent eyeliner; permanent retainer or spacer; artificial eyebrows; cardiac pacemaker; metal fragments in eye, skin, or body, including shrapnel; heart...
The study team makes the final eligibility decision.
Where it's taking place
- Austin, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 13 years to 25 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Austin, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.