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New treatment option for Obsessive Compulsive Disorder (OCD)
Official title Accelerated rTMS Therapeutic Approach for Refractory Obsessive-Compulsive Disorder
ClinicalTrials.gov ID: NCT07198594
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn if individualized accelerated repetitive transcranial magnetic stimulation (rTMS) targeting the inferior frontal cortex combined with symptom provocation works to treat obsessive-compulsive disorders (OCD) in adults. It will also learn about the safety of rTMS over right IFC.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60
You may be able to join if
- Volunteer people with Obsessive Compulsive Disorders (OCD) according to the Diagnostic and Statistical Manual of Mental Disorders (DSM V) criteria
- without associated tics ("Gilles de la Tourette" Syndrome)
- Age 18-60 years, right-handed
- Disease severity: Yale-Brown Obsessive Compulsive Scale score ≥16 for OCD patients
- Medication stable for at least 4 weeks
You likely can't join if
- Abnormal cognitive status (assessed using MoCA with score \<24);
- Other primary diagnosis than OCD (comorbid mild depression is tolerated)
- Comorbid diagnosis of schizophrenia/ psychotic disorder, bipolar disorder, substance abuse or dependance3)
- Significant self-harm intent or severe suicidal tendencies within the past year;
- Irreversible visual or auditory impairment preventing completion of scales or related assessments;
- Presence of metallic implants, such as pacemakers or stents;
See the full eligibility criteria
- Volunteer people with Obsessive Compulsive Disorders (OCD) according to the Diagnostic and Statistical Manual of Mental Disorders (DSM V) criteria
- without associated tics ("Gilles de la Tourette" Syndrome)
- Age 18-60 years, right-handed
- Disease severity: Yale-Brown Obsessive Compulsive Scale score ≥16 for OCD patients
- Medication stable for at least 4 weeks
- Resistant patients to standard treatments: partial but insufficient response (reduction of Y-BOCS score \ 12 weeks) of at least 2 Serotonin Reuptake Inhibitors (selective serotonin reuptake inhibitors, clomipramine), or...
- No systematic rTMS therapy in the past six months;
- Signature of informed consent form;
- Normal vision or corrected vision;
- Capacity to complete protocol-specified tests.
- Abnormal cognitive status (assessed using MoCA with score \<24);
- Other primary diagnosis than OCD (comorbid mild depression is tolerated)
- Comorbid diagnosis of schizophrenia/ psychotic disorder, bipolar disorder, substance abuse or dependance3)
- Significant self-harm intent or severe suicidal tendencies within the past year;
- Irreversible visual or auditory impairment preventing completion of scales or related assessments;
- Presence of metallic implants, such as pacemakers or stents;
- Any current or potential medical, psychological, social, or geographical factors compromising patient safety or study participation;
- Poor compliance;
- Claustrophobia;
- History of epilepsy or familial epilepsy
- Pregnant or lactating women (women of childbearing potential must obtain a negative pregnancy test result prior to study commencement and employ medically approved contraceptive measures);
- Deterioration or failure of vital organ function (cardiac, pulmonary, hepatic, renal, etc.); or unstable vital signs;
- Conditions unsuitable for this stimulation site, such as increased intracranial pressure, elevated intraocular pressure, or glaucoma
- History of or concomitant neurological disorders: cerebrovascular disease, central nervous system infections, Creutzfeldt-Jakob disease, Huntington's disease and Parkinson's disease, Lewy body dementia, traumatic brain...
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.