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New treatment option for Critical Care, Intensive Care
Official title CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS
ClinicalTrials.gov ID: NCT07189091
What this study is testing
What is Glucose 5% for fluid creep?
Glucose 5% for fluid creep is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for critical care, intensive care.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the body normally needs.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- At least 18 years of age
- Patients who are admitted to the ICU for medical or surgical emergencies, including complications of elective surgery
- The treating physician expects the patient will still require ICU care in two days, indicating a severe or complex condition at enrollment
- The patient is expected to receive at least 300 mL of fluid creep or at least 1 liter of maintenance fluid according to study-arm during the first...
You likely can't join if
- A contraindication to hypotonic fluids due to risk of brain edema (including traumatic brain injury, major stroke, intracranial/subarachnoid...
- Hyponatremia below 131 mmol/L at admission
- Admission solely for treatment of fluid accumulation due to cardiac decompensation, without other acute medical conditions requiring ICU-level care...
- Patient's death is deemed imminent and inevitable, admission for palliative care or admission solely for organ donation
- Patient receiving chronic renal replacement therapy
- Patients referred after a stay of more than 24 hours in another ICU
See the full eligibility criteria
- At least 18 years of age
- Patients who are admitted to the ICU for medical or surgical emergencies, including complications of elective surgery
- The treating physician expects the patient will still require ICU care in two days, indicating a severe or complex condition at enrollment
- The patient is expected to receive at least 300 mL of fluid creep or at least 1 liter of maintenance fluid according to study-arm during the first 24h after inclusion
- A contraindication to hypotonic fluids due to risk of brain edema (including traumatic brain injury, major stroke, intracranial/subarachnoid hemorrhage, meningoencephalitis, intracranial malignancies…), with the timing...
- Hyponatremia below 131 mmol/L at admission
- Admission solely for treatment of fluid accumulation due to cardiac decompensation, without other acute medical conditions requiring ICU-level care. Note: Patients with heart failure as a comorbidity, those on chronic...
- Patient's death is deemed imminent and inevitable, admission for palliative care or admission solely for organ donation
- Patient receiving chronic renal replacement therapy
- Patients referred after a stay of more than 24 hours in another ICU
- Patients assigned by chance in CRUSADERS before
- Patient is co-enrolled in an unapproved concomitant ICU-trial or in any trial with an intervention that affects fluid administration or fluid balance Additional exclusion criteria for the SALADIN nested substudy
- Patients expected to require renal replacement therapy within 24 hours
- Increased insensible fluid losses: burns, extensive wounds or skin defects or massive diarrhea,…
- Patients without a urine catheter
- Patients expected to require bladder irrigation within 24 hours
- Patients on chronic treatment with loop or thiazide diuretics (including combination preparations)
The study team makes the final eligibility decision.
Where it's taking place
- Antwerp, Belgium
- Edegem, Belgium
- Merksem, Belgium
Compensation & support
Compensation likely.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Antwerp, Belgium; Edegem, Belgium; Merksem, Belgium. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.