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New treatment option for Ewing Sarcoma
Official title Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial
ClinicalTrials.gov ID: NCT07188532
What this study is testing
What is Chemotherapy?
Chemotherapy is an investigational medicine, being studied as a potential treatment for ewing sarcoma.
Also referred to as Chemo, Chemotherapy (NOS).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This clinical trial evaluates the effect of radiotherapy doses based on tumor size and tumor-specific characteristics (biologically-adapted) in treating patients with Ewing sarcoma. Radiotherapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 2 and older
You may be able to join if
- Histological confirmation of Ewing sarcoma, including both skeletal and extra-skeletal primary tumors. Patients with "Ewing-like" sarcoma may be...
- Patients of age ≥ 2 years are eligible for the study
- Lansky or Karnofsky performance status ≥ 70
- Ability to provide written informed consent and complete questionnaire(s) by themselves or with assistance
- Willing to provide blood samples for correlative research purposes
You likely can't join if
- Prior chemotherapy or radiotherapy that, in the opinion of the treating medical oncologist or radiation oncologist, is considered to interfere with...
- Receiving any investigational agent which would be considered as a treatment for the primary neoplasm that is considered by the investigator to...
- Note: Co-enrollment on another clinical trial is allowed per the treating radiation oncologist's discretion
- Other active malignancy ≤ 1 year prior to registration that is considered by the investigator to interfere with the current treatment or measurement...
- Patients that have severe co-morbid systemic illness or other disease which would interfere significantly with the current treatment or measurement...
- Patients that have active uncontrolled systemic infection, symptomatic congestive heart failure, unstable angina, cardiac arrhythmia, or psychiatric...
See the full eligibility criteria
- Histological confirmation of Ewing sarcoma, including both skeletal and extra-skeletal primary tumors. Patients with "Ewing-like" sarcoma may be eligible if patients are planned to be treated per Ewing treatment...
- Patients of age ≥ 2 years are eligible for the study
- Lansky or Karnofsky performance status ≥ 70
- Ability to provide written informed consent and complete questionnaire(s) by themselves or with assistance
- Willing to provide blood samples for correlative research purposes
- Willing to provide biopsy sample to run Mayo Complete Solid Tumor Panel if tumor size is \>= 8 cm
- Prior chemotherapy or radiotherapy that, in the opinion of the treating medical oncologist or radiation oncologist, is considered to interfere with the current treatment or measurement of outcomes
- Receiving any investigational agent which would be considered as a treatment for the primary neoplasm that is considered by the investigator to interfere with the current treatment or measurement of outcomes
- Note: Co-enrollment on another clinical trial is allowed per the treating radiation oncologist's discretion
- Other active malignancy ≤ 1 year prior to registration that is considered by the investigator to interfere with the current treatment or measurement of outcomes
- Patients that have severe co-morbid systemic illness or other disease which would interfere significantly with the current treatment or measurement of outcomes
- Patients that have active uncontrolled systemic infection, symptomatic congestive heart failure, unstable angina, cardiac arrhythmia, or psychiatric illness or social situation that would limit study adherence
- Any of the following:
- Pregnant patients
- Nursing patients
The study team makes the final eligibility decision.
Where it's taking place
- Phoenix, Arizona, United States
- Rochester, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 2 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Phoenix, Arizona, United States; Rochester, Minnesota, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.