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New treatment option for Infertility
Official title Atosiban in Women With Previous Implantation Failure and Abnormal Uterine Contractions
ClinicalTrials.gov ID: NCT07185230
What this study is testing
What is Atosiban?
Atosiban is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for infertility.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to evaluate the efficacy of atosiban in patients with previous pregnancy failure and abnormal uterine contractions during the peri-embryo transfer period in assisted reproductive technology. The main questions it aims to answer are: Does the use of atosiban in patients with a history of implantation failure and abnormal uterine contractions affect the live birth rate in single blastocyst transfer cycles (fresh or frozen-thawed embryo transfer)?
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 to 40, women only
You may be able to join if
- Participants/eligibility criteria Infertile women who fulfill all of the following , based on the results and findings of the Atosiban 1 study are...
- Scheduled for single blastocyst-stage embryo transfer, either in a fresh or frozen transfer cycle;
- Have a history of one or more episodes of implantation failures in previous embryo transfer cycles;
- Age between 20 and 40 years (inclusive);
- Exhibit abnormal uterine peristalsis on transvaginal ultrasound performed on the morning of the scheduled blastocyst transfer, defined as either...
You likely can't join if
- Immunologic or endocrine disorders including thyroid dysfunction, antiphospholipid syndrome, hyperprolactinemia and other severe systematic diseases...
- Uterine malformations (e.g., intrauterine adhesions; unicornuate, bicornuate or septate uterus)；
- Untreated hydrosalpinx or endometrial polyp；
- Cycles that included in-vitro maturation or oocyte donation；
- Prior participation in Atosiban 1 study；
- Current participation in any other clinical trial；
See the full eligibility criteria
- Participants/eligibility criteria Infertile women who fulfill all of the following , based on the results and findings of the Atosiban 1 study are eligible for participation:
- Scheduled for single blastocyst-stage embryo transfer, either in a fresh or frozen transfer cycle;
- Have a history of one or more episodes of implantation failures in previous embryo transfer cycles;
- Age between 20 and 40 years (inclusive);
- Exhibit abnormal uterine peristalsis on transvaginal ultrasound performed on the morning of the scheduled blastocyst transfer, defined as either: high-frequency peristalsis (\>4 contractions per minute), or a negative...
- Each woman could only participate in one transfer cycle.
- Immunologic or endocrine disorders including thyroid dysfunction, antiphospholipid syndrome, hyperprolactinemia and other severe systematic diseases (e.g., hypertension, diabetes, etc.)
- Uterine malformations (e.g., intrauterine adhesions; unicornuate, bicornuate or septate uterus)；
- Untreated hydrosalpinx or endometrial polyp；
- Cycles that included in-vitro maturation or oocyte donation；
- Prior participation in Atosiban 1 study；
- Current participation in any other clinical trial；
- Inability to provide informed consent to the study.
The study team makes the final eligibility decision.
Where it's taking place
- Xi'an, Shaanxi, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 20 years to 40 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Xi'an, Shaanxi, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.