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Compares treatment options for Overactive Bladder Syndrome
Official title Platelet-Rich Plasma Versus Botulinum Toxin for Refractory Overactive Bladder: A Randomized Trial
ClinicalTrials.gov ID: NCT07184307
What this study is testing
What is Platelet-Rich Plasma?
Platelet-Rich Plasma is an investigational medicine, given as an injectable medicine, being studied as a potential treatment for overactive bladder syndrome.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Overactive bladder is a common condition that causes sudden urges to urinate, frequent urination, night-time urination, and sometimes leakage of urine. Many people with overactive bladder improve with lifestyle changes and medicines.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age 18 years or older
- History of urgency, frequency, nocturia, with or without urge urinary incontinence, lasting for at least 6 months
- Failure of standard medical treatment (antimuscarinics, beta-3 adrenergic agonists, or other appropriate therapy) for at least 6 months
- Willing and able to complete bladder diaries, questionnaires, and urodynamic testing
- Provides informed consent
You likely can't join if
- Pregnancy or lactation
- Previous intravesical biological therapy (e.g., platelet-rich plasma or botulinum toxin)
- Prior pelvic or bladder surgery that may affect bladder function
- Active urinary tract infection or sexually transmitted infection
- Vaginitis or chronic bacterial prostatitis
- Bladder or lower ureteral stones confirmed by imaging
See the full eligibility criteria
- Age 18 years or older
- History of urgency, frequency, nocturia, with or without urge urinary incontinence, lasting for at least 6 months
- Failure of standard medical treatment (antimuscarinics, beta-3 adrenergic agonists, or other appropriate therapy) for at least 6 months
- Willing and able to complete bladder diaries, questionnaires, and urodynamic testing
- Provides informed consent
- Pregnancy or lactation
- Previous intravesical biological therapy (e.g., platelet-rich plasma or botulinum toxin)
- Prior pelvic or bladder surgery that may affect bladder function
- Active urinary tract infection or sexually transmitted infection
- Vaginitis or chronic bacterial prostatitis
- Bladder or lower ureteral stones confirmed by imaging
- Bladder outlet obstruction on urodynamic study
- Bladder malignancy (mass on imaging or malignant cells on cytology)
- Use of indwelling urinary catheter
- Severe uncontrolled medical conditions (e.g., uncontrolled diabetes, advanced renal or hepatic impairment)
- Known hypersensitivity to botulinum toxin or contraindication to platelet-rich plasma preparation (e.g., coagulopathy, inability to discontinue anticoagulation safely)
The study team makes the final eligibility decision.
Where it's taking place
- Banhā, Qalyubia Governorate, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Banhā, Qalyubia Governorate, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.