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New treatment option for Renal Cell Carcinoma (Kidney Cancer)
Official title Targeted Abdominal CT in Conjunction With Lung Cancer Screening
ClinicalTrials.gov ID: NCT07171190
What this study is testing
- What it's testing
- Early detection through screening can improve cancer survival by identifying it when it's most treatable. The NHS now offers Lung Cancer Screening (LCS) assessments to people aged 55-74 who have ever smoked.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 70. Healthy volunteers may be eligible.
You may be able to join if
- For the individual level randomisation to invitation control or invitation intervention To be assigned by chance at the individual level to receive...
- Be eligible to be invited to the first round of a West Yorkshire and Harrogate LCS or a Humber and North Yorkshire Cancer Alliance LCS (i.e. have...
- Be registered with a GP in England.
- Be aged 55-70 years 364 days old at the date of invitation.
You likely can't join if
- None
- Eligibility criteria for the cluster level randomisation to scan intervention or scan control Inclusion criteria a): To be eligible for the cluster...
- Have been individually assigned by chance to the invitation intervention arm
- Have booked in for a LCS assessment Inclusion criteria b): To receive the CT Thorax plus ANCCT, the participant must:
- Have been assigned by chance to the scan intervention cluster
- Be invited to attend for a LDCT Thorax based upon scores on either PLCOM2012 or Liverpool Lung Project (LLP) risk prediction models (PLCOM2012 risk...
See the full eligibility criteria
- For the individual level randomisation to invitation control or invitation intervention To be assigned by chance at the individual level to receive an invitation letter for LCS (standard of care; invitation control)...
- Be eligible to be invited to the first round of a West Yorkshire and Harrogate LCS or a Humber and North Yorkshire Cancer Alliance LCS (i.e. have been identified as a smoker or ex-smoker and registered as living within...
- Be registered with a GP in England.
- Be aged 55-70 years 364 days old at the date of invitation.
- None
- Eligibility criteria for the cluster level randomisation to scan intervention or scan control Inclusion criteria a): To be eligible for the cluster level randomisation the participant must:
- Have been individually assigned by chance to the invitation intervention arm
- Have booked in for a LCS assessment Inclusion criteria b): To receive the CT Thorax plus ANCCT, the participant must:
- Have been assigned by chance to the scan intervention cluster
- Be invited to attend for a LDCT Thorax based upon scores on either PLCOM2012 or Liverpool Lung Project (LLP) risk prediction models (PLCOM2012 risk of ≥1.51% over six years or LLPver2 five-year risk of ≥2.5%)14 during...
- Have attended the lung scan appointment
- Have given electronic or written informed consent to participate Exclusion criteria Existing LCS exclusion criteria:
- Participant does not have capacity to give consent (standard criteria for assessing capacity apply).
- Weight or physical size exceeds restrictions for scanner (\>200kg).
- Participant unable to lie flat.
- Poor physical fitness such that treatment with curative intent would be contra-indicated.
- Participants who have had a full CT Thorax that meets the image reconstruction parameters of the programme in the last 12 months are not excluded from the lung screening programme, but would have their CT Thorax...
- Had an abdominal CT in the previous 12 months or has one booked within the next 3 months.
- For HNY, this is checked before the LCS assessment. Therefore, participants will be excluded before the LCS assessment.
- For WYH, this is only checked after the LCS assessment. Therefore, anyone having had an abdominal CT in the previous 12 months or with one booked within the next 3 months will be excluded at this point (see 8.6).
- Eligibility criteria for the process evaluation Health care professionals: Healthcare professionals involved in the delivery of LCS in any of the study areas who agree to take part. Participants: People individually...
The study team makes the final eligibility decision.
Where it's taking place
- Hull, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hull, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.