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New treatment option for Muscle Weakness
Official title Mitigating Neural Hypoexcitability and Weakness During Disuse in Women
ClinicalTrials.gov ID: NCT07166198
What this study is testing
- What it's testing
- Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife. The main questions it aims to answer are: What changes happen in the nervous system that lead to weakness when a wrist is immobilized?
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 65, women only. Healthy volunteers may be eligible.
You may be able to join if
- Women between 40-65 years of age
- Baseline handgrip strength \>16Kg
You likely can't join if
- Personal or family history of blood clots
- Current use of anticoagulant medications
- Neuromuscular or metabolic diseases (e.g., multiple sclerosis, diabetes)
- Arthritis
- Osteoporosis or osteopenia
- History of myocardial infarction within the past year
See the full eligibility criteria
- Women between 40-65 years of age
- Baseline handgrip strength \>16Kg
- Personal or family history of blood clots
- Current use of anticoagulant medications
- Neuromuscular or metabolic diseases (e.g., multiple sclerosis, diabetes)
- Arthritis
- Osteoporosis or osteopenia
- History of myocardial infarction within the past year
- Chronic pain ≥3/10 for ≥3 months
- Uncontrolled hypertension (≥140/90 mmHg)
- Upper extremity surgery within the past year
- Use of assistive hand or arm device within the past year
- Fall involving the upper extremities within the past year
- Upper extremity injuries preventing safe participation
- Current use of muscle relaxants, benzodiazepines, or similar drugs
- Smoking within the past 6 months
- History of drug or alcohol abuse within the past year
- Severe anxiety or claustrophobia
- Pregnancy (current or planned)
- Allergies to medical adhesives
- High risk of sarcopenia (per SARC-F)
- Contraindications to TMS or MRI
- Upper-body resistance training within the past 6 months
- Inability/unwillingness to refrain from resistance training during study
The study team makes the final eligibility decision.
Where it's taking place
- Manhattan, Kansas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 40 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Manhattan, Kansas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.