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New treatment option for Brain (Nervous System) Cancers
Official title Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases
ClinicalTrials.gov ID: NCT07162246
What this study is testing
- What it's testing
- When cancer spreads to the brain, doctors often use a precise type of radiation therapy called stereotactic radiosurgery (SRS) to treat these tumors. This treatment can effectively control brain tumors while helping protect healthy brain tissue.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Presence of up to two large intracranial lesions
- Up to 10 (previously untreated, or progressing after previous treatment) brain metastases at the time of enrollment on the diagnostic MRI (which...
- Age =\> 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
- Expected survival \>3 months
You likely can't join if
- Prior SRS to the ILLs
- Prior WBRT, or plan for concurrent WBRT with the protocol treatment
- Presence or history of any leptomeningeal/pachymeningeal disease
- Metastatic disease within the ventricles of the brain or corpus callosum
- Small cell, hematopoietic or germ cell primaries
- Patient with absolutely contraindications for MRI
See the full eligibility criteria
- Presence of up to two large intracranial lesions
- Up to 10 (previously untreated, or progressing after previous treatment) brain metastases at the time of enrollment on the diagnostic MRI (which includes the ILLs) to be treated with SRS/HSRS
- Age =\> 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
- Expected survival \>3 months
- Patients that are deemed suitable for both GK and Linac based treatment
- Patients that are able to hold systemic cancer chemotherapy/immunotherapy at least 2 days prior and following an SRS fraction
- Prior SRS to the ILLs
- Prior WBRT, or plan for concurrent WBRT with the protocol treatment
- Presence or history of any leptomeningeal/pachymeningeal disease
- Metastatic disease within the ventricles of the brain or corpus callosum
- Small cell, hematopoietic or germ cell primaries
- Patient with absolutely contraindications for MRI
- Severe symptoms that preclude MRI or treatment using standard procedures for Linac or GK
- Pregnant or lactating patient
- Inability or unwillingness to undergo informed consent or post-treatment follow-up
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.