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New treatment option for Mitochondrial Energetics
Official title Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
ClinicalTrials.gov ID: NCT07161973
What this study is testing
- What it's testing
- Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition affecting untold millions of individuals each year. Such disuse leads to a rapid decline in muscle fiber area and hence whole muscle size, contributing to a decrease in strength, speed, and power as well as alterations in energy metabolism.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 44, men only. Healthy volunteers may be eligible.
You may be able to join if
- Men age 18-44
- Above the minimum threshold of the IPAQ questionnaire
- Below the maximum threshold of the IPAQ questionnaire
You likely can't join if
- Men and women \ 44 years of age
- Unable to provide informed consent
- Known clotting disorder
- Previous history of deep vein thrombosis
- Injury to either leg resulting in reduced mobility in the previous year
- Currently dieting or weight instability for the past 3 months
See the full eligibility criteria
- Men age 18-44
- Above the minimum threshold of the IPAQ questionnaire
- Below the maximum threshold of the IPAQ questionnaire
- Men and women \ 44 years of age
- Unable to provide informed consent
- Known clotting disorder
- Previous history of deep vein thrombosis
- Injury to either leg resulting in reduced mobility in the previous year
- Currently dieting or weight instability for the past 3 months
- Epileptic
- Pacemaker or other implantable heart device
- Currently taking antibiotics
- Current smoker
- Stage II hypertension (resting blood pressure \>140/\>90)
- Previously undergone a revascularization procedure involving a vascular graft or stenting of the femoral or popliteal arteries
- Those taking phosphodiesterase inhibitors (e.g., Viagra), proton pump inhibitors, antacids, xanthine oxidase inhibitors, hormonal contraceptives or on hormone replacement therapy
- An answer of yes to any of the seven questions on the first page of the Physical Activity Readiness Questionnaire (PAR-Q. These exclusions include the following:
- If participant's doctor has ever said that he/she has a heart condition and that he/she should only do physical activity recommended by a doctor
- Pain in chest when doing physical activity
- In past month, chest pain when not doing physical activity
- If participant has ever lost balance because of dizziness or has ever lost consciousness
- Muscle, bone, or joint problem that could be made worse by physical activity
- Currently on prescribed drugs for blood pressure or heart condition.
- If the participant knows of any other reason he/she should not do physical activity.
The study team makes the final eligibility decision.
Where it's taking place
- Indianapolis, Indiana, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 18 years to 44 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Indianapolis, Indiana, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.