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New treatment option for Osteo Arthritis of the Knee
Official title Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA
ClinicalTrials.gov ID: NCT07161336
What this study is testing
What is Methotrexate (MTX)?
Methotrexate (MTX) is an investigational medicine, being studied as a potential treatment for osteo arthritis of the knee.
Also referred to as MTX, Low dose Methotrexate.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Background: Osteoarthritis (OA) is a leading cause of disability worldwide, with limited treatment options and many patients suffering from chronic pain. Modern imaging has revealed that OA involves complex changes in cartilage, subchondral bone, and synovium.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 70
You may be able to join if
- Men and women aged between 40 to 70 years
- Patients fulfilling American College of Rheumatology (ACR) clinical and radiological criteria for knee OA. (knee pain + at least 3 of 5 that not...
- Knee pain on most days for at least 6 months, with a pain VAS of at least 40mm
- Radiological grading of OA with Kallgren-Lawrence grade of 2 to 3
- Patients with the presence of knee synovitis in Musculoskeletal ultrasound
You likely can't join if
- Any known inflammatory arthritis
- BMI \>= 40 kg/m2
- Abnormal renal (e.g. abnormal renal function Creatinine clearance \<35 ml) hepatic (including active hepatitis B, hepatitis C, abnormal liver...
- Use of intra-articular, intramuscular or oral corticosteroids in previous 4 weeks
- History knee joint surgery, Charcot joint
- Severe valgus knee deformity (angle of genu valgum \> 30°)
See the full eligibility criteria
- Men and women aged between 40 to 70 years
- Patients fulfilling American College of Rheumatology (ACR) clinical and radiological criteria for knee OA. (knee pain + at least 3 of 5 that not including "no palpable warmth")
- Knee pain on most days for at least 6 months, with a pain VAS of at least 40mm
- Radiological grading of OA with Kallgren-Lawrence grade of 2 to 3
- Patients with the presence of knee synovitis in Musculoskeletal ultrasound
- Any known inflammatory arthritis
- BMI \>= 40 kg/m2
- Abnormal renal (e.g. abnormal renal function Creatinine clearance \<35 ml) hepatic (including active hepatitis B, hepatitis C, abnormal liver function), hematological (e.g. white cell count \< 4 × 109/L, platelets \<100...
- Use of intra-articular, intramuscular or oral corticosteroids in previous 4 weeks
- History knee joint surgery, Charcot joint
- Severe valgus knee deformity (angle of genu valgum \> 30°)
- Use of any disease modifying agents (e.g. hydroxychloroquine or sulfasalazine) in previous 3 months
- Allergic to MTX
- Pregnant or lactating women
The study team makes the final eligibility decision.
Where it's taking place
- Dhaka, Dhaka Division, Bangladesh
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dhaka, Dhaka Division, Bangladesh. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.