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Tests treatment safety and results for ACL Surgery
Official title Efficacy of Methylprednisolone for Pain Control After ACL Repair
ClinicalTrials.gov ID: NCT07158476
What this study is testing
What is Meloxicam 15 mg?
Meloxicam 15 mg is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for acl surgery.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 13 to 50
You may be able to join if
- Patient undergoing ACL repair or ACL reconstruction with tendon autograft
- Age 13-50 years old
- Able to provide informed consent or parent/legal guardian is able for minors
You likely can't join if
- Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater)
- Revision ACL reconstruction
- Concomitant additional ligament reconstruction or high tibial osteotomy
- A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ×2 within 6 months of the surgery)
- A history of renal failure (\ B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain...
- A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation.
See the full eligibility criteria
- Patient undergoing ACL repair or ACL reconstruction with tendon autograft
- Age 13-50 years old
- Able to provide informed consent or parent/legal guardian is able for minors
- Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater)
- Revision ACL reconstruction
- Concomitant additional ligament reconstruction or high tibial osteotomy
- A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ×2 within 6 months of the surgery)
- A history of renal failure (\ B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain perception, and pre-existing immune suppression.
- A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation.
- Patients currently taking oral or injectable glucocorticoids and those who have taken either within 1 month of the procedure.
- Patients who are currently pregnant.
- Patients who are unable to undergo the multimodal pain standardized protocol including those with comorbidities or medical allergies precluding the use of corticosteroids, gabapentin, hydrocodone, acetaminophen...
The study team makes the final eligibility decision.
Where it's taking place
- St Louis, Missouri, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 13 years to 50 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include St Louis, Missouri, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.