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New treatment option for Elevated Lp(a)
Official title Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
ClinicalTrials.gov ID: NCT07157774
What this study is testing
What is Muvalaplin?
Muvalaplin is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for elevated lp(a).
Also referred to as LY3473329.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Have Lp(a) ≥175 nanomoles per liter (nmol/L)
- Meet one of the following criteria:
- Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart...
- Are at risk for a first ASCVD event, defined as one or more of the following:
- Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event
You likely can't join if
- Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other...
- Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study
- Have uncontrolled high blood pressure
- Have New York Heart Association (NYHA) class III or IV heart failure
- Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study
- Have severe kidney impairment
See the full eligibility criteria
- Have Lp(a) ≥175 nanomoles per liter (nmol/L)
- Meet one of the following criteria:
- Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening
- Are at risk for a first ASCVD event, defined as one or more of the following:
- Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event
- A high coronary artery calcium (CAC) score
- Reduced kidney function with diabetes
- Combination(s) of high risk factors
- Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between...
- Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study
- Have uncontrolled high blood pressure
- Have New York Heart Association (NYHA) class III or IV heart failure
- Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study
- Have severe kidney impairment
- Have had cancer within 5 years prior to screening
The study team makes the final eligibility decision.
Where it's taking place
- Apache Junction, Arizona, United States
- Gilbert, Arizona, United States
- Phoenix, Arizona, United States
- Sun City West, Arizona, United States
- Surprise, Arizona, United States
- Tucson, Arizona, United States
- Beverly Hills, California, United States
- Concord, California, United States
- Escondido, California, United States
- Fountain Valley, California, United States
- Huntington Beach, California, United States
- La Jolla, California, United States
- Redding, California, United States
- Torrance, California, United States
- Aurora, Colorado, United States
- Colorado Springs, Colorado, United States
- Golden, Colorado, United States
- Stamford, Connecticut, United States
- Waterbury, Connecticut, United States
- Boca Raton, Florida, United States
+ 525 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Apache Junction, Arizona, United States; Gilbert, Arizona, United States; Phoenix, Arizona, United States; Sun City West, Arizona, United States; Surprise, Arizona, United States; Tucson, Arizona, United States and 539 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.