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New treatment option for Perennial Allergic Rhinitis
Official title Investigation of the Effects of a Multispecies Probiotic Formulation on Perennial Allergic Rhinitis
ClinicalTrials.gov ID: NCT07157462
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn if a probiotic formulation consisting of multiple bacterial strains has a positive effect on the quality of life of participants with chronic perennial allergic rhinitis symptoms. The researchers will also study whether the probiotic formulation influences the symptoms of allergic rhinitis.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults aged ≥18 years
- Willing and able to provide informed consent in French
- Persistent perennial allergic rhinitis induced by a least one perennial allergen in the last two years.
- Positive skin prick test ≥5 mm for any of the following allergens: cat, dog and mites
- Mean global score of miniRQLQ ≥ 2
You likely can't join if
- Non-allergic rhinitis
- Use of any prohibited medication (any systemic corticosteroids, androgens such as testosterone, or high doses of anti-inflammatory drugs: i.e...
- Use of other probiotics-containing and prebiotics-containing products during the intervention period and 4 weeks before study start
- Use of any antibiotics 6 weeks before randomization
- Nasal polyposis
- Currently enrolled in another intervention study (except observational studies)
See the full eligibility criteria
- Adults aged ≥18 years
- Willing and able to provide informed consent in French
- Persistent perennial allergic rhinitis induced by a least one perennial allergen in the last two years.
- Positive skin prick test ≥5 mm for any of the following allergens: cat, dog and mites
- Mean global score of miniRQLQ ≥ 2
- TSS score of at least 7
- Willing to discontinue consumption of fermented foods, probiotics (e.g., yogurts with live, active cultures or supplements), prebiotics or immune-enhancing supplements (e.g., Echinacea or fish oil).
- Agreement on not starting new medication during the intervention (rescue medication excepted)
- Women of childbearing potential with a negative pregnancy test throughout the study period and highly effective contraception: oral contraceptives, condom with spermicide, intrauterine device, bilateral tubal ligation...
- Non-allergic rhinitis
- Use of any prohibited medication (any systemic corticosteroids, androgens such as testosterone, or high doses of anti-inflammatory drugs: i.e., aspirin in doses 600 mg/d regularly) at the time of enrolment
- Use of other probiotics-containing and prebiotics-containing products during the intervention period and 4 weeks before study start
- Use of any antibiotics 6 weeks before randomization
- Nasal polyposis
- Currently enrolled in another intervention study (except observational studies)
- Critically or terminally ill or admitted to the ICU
- Had received chemotherapy or other immune-suppressing therapy within the previous year.
- Other conditions that according to the investigator might interfere with the evaluation of the study objectives
- Patients being treated for or had any of the following physician-diagnosed diseases or conditions: HIV; immune modulating diseases (autoimmune disease, hepatitis, cancer, etc.); kidney disease; pancreatitis; pulmonary...
- people with a low compliance rate (appreciated by the investigator) during the run-in period
The study team makes the final eligibility decision.
Where it's taking place
- Strasbourg, Alyatec, France
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Strasbourg, Alyatec, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.