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New treatment option for Adequate Vitamin C Status
Official title Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity
ClinicalTrials.gov ID: NCT07151105
What this study is testing
- What it's testing
- This study is testing whether taking vitamin C every day can help improve gut health and reduce inflammation in adults with obesity. Poor gut health-sometimes called "leaky gut"-can allow harmful substances from bacteria to enter the bloodstream, which may lead to inflammation and increase the risk of heart disease and liver problems.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50
You may be able to join if
- English speaking
- Men and women between 18-50 years of age
- BMI 30-40 kg/m²
- Resting blood pressure \<140/90 mm Hg
- No use of multivitamin/vitamin C supplement within past 1-month
You likely can't join if
- Current smoker or vaper, including tobacco, cannabis, or nicotine products
- Alcohol consumption \>2 drinks/day
- Use of antibiotics within past 1-month
- Use of probiotic supplements within past 1-month
- Use of anti-inflammatory drugs within past 1-month
- Individuals with unmanaged or poorly controlled diabetes, dyslipidemia, hypertension
See the full eligibility criteria
- English speaking
- Men and women between 18-50 years of age
- BMI 30-40 kg/m²
- Resting blood pressure \<140/90 mm Hg
- No use of multivitamin/vitamin C supplement within past 1-month
- Non-vegetarian/non-vegan
- Willingness to follow a diet low in fruits and vegetables for two, 2-week periods
- Current smoker or vaper, including tobacco, cannabis, or nicotine products
- Alcohol consumption \>2 drinks/day
- Use of antibiotics within past 1-month
- Use of probiotic supplements within past 1-month
- Use of anti-inflammatory drugs within past 1-month
- Individuals with unmanaged or poorly controlled diabetes, dyslipidemia, hypertension
- Known history of bleeding disorders, hemochromatosis, or kidney stones
- For Women: Pregnancy, lactation, or change in birth control within the past 3-months
- Use of certain medications that may interact with vitamin C, including blood thinners, some antiviral drugs (e.g., indinavir), and certain antipsychotic medications (e.g., fluphenazine).
The study team makes the final eligibility decision.
Where it's taking place
- Columbus, Ohio, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 50 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Columbus, Ohio, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.