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New treatment option for Moyamoya Disease
Official title Cognitive-Motor Incorporated Training and Its Relations in Cerebrovascular Diseases With Cognitive and Motor Impairments
ClinicalTrials.gov ID: NCT07144930
What this study is testing
- What it's testing
- The following three-part proposal will explore the impact of applying motor-cognitive incorporated training (MCIT) in individuals with post-stroke cognitive impairment (PSCI) or Moyamoya disease (MMD), and examine the relationship between cognitive and motor impairments and brain activation patterns in these populations. Part I is a cross-sectional study designed to characterize cognitive and motor performance and their relationship with brain activation patterns in individuals with post-stroke cognitive impairment (PSCI) or Moyamoya disease (MMD), compared to age-matched healthy controls.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 to 100. Healthy volunteers may be eligible.
You may be able to join if
- Part 1:
- For aged-matched healthy controls:
- being 20 years of age or older
- the ability to stand for more than 30 seconds
- a MoCA score of higher than 26.
You likely can't join if
- unstable or uncontrolled vital signs, including a resting heart rate \>100 or \ 20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial...
- requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
- the presence of other neurological disorders or unstable vital signs may interfere with the experiment
- currently hospitalized in the intensive care unit (ICU)
- Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation Part 2: Inclusion...
- Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
See the full eligibility criteria
- Part 1:
- For aged-matched healthy controls:
- being 20 years of age or older
- the ability to stand for more than 30 seconds
- a MoCA score of higher than 26.
- For PSCI participants:
- Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
- Being 20 years of age or older
- The ability to stand for more than 30 seconds
- a MoCA score of less than 26
- For the MMD group:
- a confirmed diagnosis of Moyamoya disease or Moyamoya syndrome through CT scan or angiography
- If stroke occurred, being in the subacute phase (one week post-stroke)
- being 20 years of age or older
- the ability to stand for more than 30 seconds
- a MoCA score of less than 26
- unstable or uncontrolled vital signs, including a resting heart rate \>100 or \ 20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will...
- requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
- the presence of other neurological disorders or unstable vital signs may interfere with the experiment
- currently hospitalized in the intensive care unit (ICU)
- Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation Part 2: Inclusion Criteria:
- Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase)
- Being 20 years of age or older
- The ability to stand for more than 30 seconds
- a MoCA score of less than 26 Exclusion Criteria:
- unstable or uncontrolled vital signs, including a resting heart rate \>100 or \ 20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will...
- requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
- the presence of other neurological disorders or unstable vital signs may interfere with the experiment
- currently hospitalized in the intensive care unit (ICU)
- Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation Part 3: Inclusion Criteria:
- Moyamoya disease/syndrome confirmed through CT scan or angiography
- being in the subacute phase, defined as one week after stroke onset
- being 20 years of age or older
- the ability to stand for more than 30 seconds
- a Montreal Cognitive Assessment (MoCA) score of less than 26. Exclusion Criteria:
- unstable or uncontrolled vital signs, including a resting heart rate \>100 or \ 20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will...
- requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions
- the presence of other neurological disorders or unstable vital signs that could interfere with the experiment
- currently hospitalized in the intensive care unit (ICU)
- Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation.
The study team makes the final eligibility decision.
Where it's taking place
- Taipei, Taiwan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 20 years to 100 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Taipei, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.