BridgeMD
New treatment option for Aging
Official title Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults
ClinicalTrials.gov ID: NCT07144527
What this study is testing
- What it's testing
- This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of a patented age-reversal therapy, EGA®, compared to conventional nicotinamide mononucleotide (NMN) supplementation. The study will assess safety and efficacy in improving exercise tolerance and modulating biomarkers of aging in healthy older adults.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 to 80. Healthy volunteers may be eligible.
You may be able to join if
- Adults aged 60 to 80 years, of any sex
- Written clearance from primary care physician confirming medical fitness to participate in an exercise-based clinical study
- Normal or near-normal cardiovascular function to safely engage in moderate to vigorous exercise, demonstrated by either: stress echocardiogram or...
- Montreal Cognitive Assessment (MoCA) score of 26 or higher
- Free from acute or uncontrolled chronic medical conditions that would pose a risk or interfere with study participation
You likely can't join if
- Severe cardiovascular disease (e.g., recent myocardial infarction \ 160/100 mmHg)
- Severe respiratory conditions (e.g., advanced COPD or other conditions preventing exercise participation)
- Significant neurological impairments that hinder comprehension of instructions or participation in exercise
- Terminal illness or conditions limiting life expectancy or ability to complete the study
- Severe cognitive impairment preventing informed consent, protocol adherence, or comprehension of interventions
- Significant orthopedic limitations or injuries that prevent safe exercise participation
See the full eligibility criteria
- Adults aged 60 to 80 years, of any sex
- Written clearance from primary care physician confirming medical fitness to participate in an exercise-based clinical study
- Normal or near-normal cardiovascular function to safely engage in moderate to vigorous exercise, demonstrated by either: stress echocardiogram or coronary CT angiogram within the past 12 months showing normal left...
- Montreal Cognitive Assessment (MoCA) score of 26 or higher
- Free from acute or uncontrolled chronic medical conditions that would pose a risk or interfere with study participation
- Physically capable of engaging in structured exercise involving moderate to vigorous intensity stationary cycling
- Successful completion of a graded exercise test (e.g., stationary bike) without significant adverse events or contraindications
- Ability to attend at least four in-person laboratory visits in Beverly Hills, California
- Non-smoker for at least 12 months
- Able to provide informed consent and comply with study procedures
- Willing to refrain from initiating new exercise, dietary supplement, or medication regimens during the study
- Severe cardiovascular disease (e.g., recent myocardial infarction \ 160/100 mmHg)
- Severe respiratory conditions (e.g., advanced COPD or other conditions preventing exercise participation)
- Significant neurological impairments that hinder comprehension of instructions or participation in exercise
- Terminal illness or conditions limiting life expectancy or ability to complete the study
- Severe cognitive impairment preventing informed consent, protocol adherence, or comprehension of interventions
- Significant orthopedic limitations or injuries that prevent safe exercise participation
- Use of NMN, NR, or other NAD+-altering supplements within the past 14 weeks
- Anticipated or current alcohol consumption \>2 drinks per week, or unwillingness to abstain from alcohol during the study
- Current substance abuse affecting study participation or adherence
- Other acute or chronic health conditions judged by the investigators to pose risk or interfere with study objectives
- Non-compliance with study requirements, withdrawal of informed consent, or unforeseen circumstances compromising completion
- Any condition which, in the opinion of the investigator, would interfere with study participation or interpretation of results
The study team makes the final eligibility decision.
Where it's taking place
- Beverly Hills, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years to 80 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beverly Hills, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.