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New treatment option for Iron Absorption
Official title Determination of Iron Absorption and Losses in People Living at High Altitude to Investigate the Requirements in This Population Group Using a Newly Developed Technique
ClinicalTrials.gov ID: NCT07142590
What this study is testing
- What it's testing
- Iron is an essential micronutrient responsible for a whealth of biological processes of the human body. Iron plays a fundamental role especially in oxygen transport, by binding to hemoglobin in the blood circulation.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 45. Healthy volunteers may be eligible.
You may be able to join if
- Females and males aged 18-45 y
- BMI: 18 to 25 kg/m2
- Body weight \<70 kg for females, \<85 kg for males
- Plasma ferritin \>25 µg/L
- Signed informed consent
You likely can't join if
- Hb \<12 g/dL (females), Hb \<13 g/dL (males), corrected for altitude using the 2024 WHO guidance values for hemoglobin adjustments
- Inflammation (CRP \> 5 mg/L)1
- Plasma ferritin \>150 µg/L for females and \>200 µg/L for males
- Chronic disease known to affect iron metabolism
- Chronic medications (except for oral contraceptives)
- Pregnancy (tested at screening) or intention to become pregnant during the course of the study
See the full eligibility criteria
- Females and males aged 18-45 y
- BMI: 18 to 25 kg/m2
- Body weight \<70 kg for females, \<85 kg for males
- Plasma ferritin \>25 µg/L
- Signed informed consent
- Hb \<12 g/dL (females), Hb \<13 g/dL (males), corrected for altitude using the 2024 WHO guidance values for hemoglobin adjustments
- Inflammation (CRP \> 5 mg/L)1
- Plasma ferritin \>150 µg/L for females and \>200 µg/L for males
- Chronic disease known to affect iron metabolism
- Chronic medications (except for oral contraceptives)
- Pregnancy (tested at screening) or intention to become pregnant during the course of the study
- Lactation
- High physical activity (MET-min/week \> 3000 calculated according to the IPAQ, short version, administered at the screening)
- Difficulty with blood withdrawal
- Earlier participation in a study using stable iron isotopes or participation in any clinical study within the last 30 days
- Smoking
- Blood donation, blood transfusion or significant blood loss (more than 400 mL) over the past 6 months
- Intention to regularly donate blood during the 2 years duration of the study
- No residence in the respective location/altitude for at least the last 2 years
- No intention to reside in the respective location/altitude at least for the next 2 years
- Participants who are planning to spend an extended period (\>12 weeks) at a different altitude from their residence location
- Spending more than 2 nights per week at a different location from residence location
- Inability to understand the information sheet and the informed consent form due to cognitive or language reasons
The study team makes the final eligibility decision.
Where it's taking place
- Zurich, Canton of Zurich, Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 45 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Zurich, Canton of Zurich, Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.