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New treatment option for Blast Injury
Official title Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
ClinicalTrials.gov ID: NCT07131475
What this study is testing
What is PBR28 TSPO PET?
PBR28 TSPO PET is an investigational medicine, being studied as a potential treatment for blast injury.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that detects repeated blast brain injury.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50, men only
You may be able to join if
- Active-duty Navy SEAL Service Member
- Early career SEAL (0-2 years) or mid-late career SEAL (10-15 years)
- Age 18-50 years
- Males, regardless of race or ethnicity
You likely can't join if
- History of moderate or severe TBI
- History of major neurological disorder
- Untreated or unstable severe psychiatric condition
- Current severe medical condition that requires long-term treatment
- Any condition that may cause undue risk to the participant or create a logistical contraindication
- MRI contraindication
See the full eligibility criteria
- Active-duty Navy SEAL Service Member
- Early career SEAL (0-2 years) or mid-late career SEAL (10-15 years)
- Age 18-50 years
- Males, regardless of race or ethnicity
- History of moderate or severe TBI
- History of major neurological disorder
- Untreated or unstable severe psychiatric condition
- Current severe medical condition that requires long-term treatment
- Any condition that may cause undue risk to the participant or create a logistical contraindication
- MRI contraindication
- PET contraindication
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 18 years to 50 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.